380897-87-0

Upstream product

• 535-11-5 Ethyl 2-bromopropionate 
• 5334-23-6 tisopurine 
• 380897-81-4 2-(1H-pyrazolo[3,4-d]pyrimidin-4-ylsulfanyl)-propionic acid ethyl ester 
• 380897-71-2 (3-acetoxy-2-O-benzoyl-1-propoxy)methyl bromide 

Relevant academic research and scientific papers

Synthesis of some acyclonucleosides α-(pyrazolo[3,4-d]pyrimidin-4-ylthio)-alkylamides

The synthesis of some acyclic α-(pyrazolo[3,4-d]pyrimidin-4-ylthio)alkylamide nucleosides is described.

Synthesis and biological evaluation of some acyclic α-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)thioalkylamide nucleosides

The chemical synthesis of some acyclic α-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)thioalkylamide nucleosides (10-12)a-c is described. The treatment of 1H-pyrazolo[3,4-d]pyrimidin-4-thione 1 with compounds 2a-c gave, regioselectively, ethyl α-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)thioalkylates 3a-c, respectively. These heterocycles were alkylated, separately, with alkylating agents 4, 5 and 6 to give, regioselectively, the N1-acyclic nucleosides (7-9)a-c which were deprotected to afford the desired products (10-12)a-c. All synthetic compounds were characterized on the basis of their physical and spectroscopic properties. The products (10-12)a-c were evaluated for their inhibitory effects against the replication of HIV-1 (IIIB), HIV-2 (ROD), various DNA viruses, a variety of tumor-cell lines and M. tuberculosis. No marked biological activity was found.