380905-53-3

Upstream product

• 3413-15-8 butylphthalide 
• 380905-54-4 C₁₂H₁₆O₃*C₈H₁₁N 
• 380905-48-6 (±)-2-(1-hydroxypentyl)benzoic acid 
• 162050-42-2 3-hydroxy-3-butyl-1(3H)-isobenzofuranone 

Downstream Products

• 1410729-11-1 (R)-(+)-2-[1-(2-chloroacetoxy)pentyl]benzoic acid 
• 1428866-34-5 (R)-2-(1-acetoxy-n-pentyl)benzoic acid 
• 1411120-20-1 (S)-ZJM-289 
• 1410729-25-7 C₃₂H₄₂N₂O₁₀*ClH 

Relevant academic research and scientific papers

Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents

In search of novel anti-ischemic stroke agents with higher potency than a known drug 3-n-butylphthalide (NBP), a series of hybrids ((S)- and (R)-5a-f) from optically active ring-opened NBP derivative and isosorbide were synthesized for evaluating their anti-ischemic stroke activity. Compound (S)-5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation in vitro, with 10.0- and 8.4-fold more effectiveness than (S)-NBP, respectively. Furthermore, (S)-5e was stable in artificial gastrointestinal fluids and could penetrate the blood-brain barrier (BBB) with an appreciate lipid/water partition coefficient relative to (S)-NBP. More importantly, oral treatment with (S)-5e protected from acute thrombosis and inhibited the ischemia/reperfusion-related brain injury in animals. Our findings suggest that (S)-5e may be promising for further evaluation for the intervention of ischemic stroke.

Studies on the enantiomers of ZJM-289: Synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities

ZJM-289 is a potent racemic agent which inhibits both platelet aggregation and thrombosis superior to a known anti-ischemic stroke drug 3-n-butylphthalide (NBP). Herein, the enantiomers of ZJM-289, (S)-ZJM-289 and (R)-ZJM-289, were synthesized and evaluat

Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone

A series of 3-substituted-1(3H)-isobenzofuranone 6a-g and 7a-g were synthesized from phthalic anhydride. The compound 6a-g was resolved. The antiplatelet activities of these compounds were evaluated using in vitro experiment of platelet aggregation. The levels of antiplatelet activity were displayed as following sequence: l-isomer > dl-isomer > d-isomer, respectively. The alkylphthalide is more active than the corresponding alkenephthalide. All these compounds were less active than n-butylphthalide (NBP, 6c) and Aspirin (Asp).