38093-76-4

Basic information

• Product Name: 2-methyl-4-phenylthiazol-5-Amine
• Synonyms: 2-methyl-4-phenylthiazol-5-Amine;2-methyl-4-phenyl-5-Thiazolamine;2-methyl-4-phenylthiazol-5-ylamine
• CAS NO: 38093-76-4
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.2648
• Mol File: 38093-76-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 349.7 °C at 760 mmHg
• Flash Point: 165.3 °C
• Appearance: /
• Density: 1.219 g/cm³
• CAS DataBase Reference: 2-methyl-4-phenylthiazol-5-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-phenylthiazol-5-Amine(38093-76-4)
• EPA Substance Registry System: 2-methyl-4-phenylthiazol-5-Amine(38093-76-4)

Safety Data

• Hazardous Substances Data: 38093-76-4(Hazardous Substances Data)

Usage

General Description

2-methyl-4-phenylthiazol-5-amine is a chemical compound belonging to the thiazole class of organic compounds. It is a derivative of thiazole, which is a five-membered heterocyclic ring containing one sulfur and one nitrogen atom. 2-methyl-4-phenylthiazol-5-Amine can be synthesized through various chemical reactions and is used in the field of medicinal chemistry for the development of new pharmaceutical drugs. It has been studied for its potential biological activities and has shown to exhibit anti-inflammatory and antioxidant properties. Additionally, its structure and reactivity make it a valuable building block in the synthesis of complex organic molecules. Overall, 2-methyl-4-phenylthiazol-5-amine is a versatile chemical compound with potential applications in pharmaceutical and organic synthesis.

Upstream product

• 39149-34-3 2-acetamido-2-phenylacetonitrile 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 1041436-27-4 (2-methyl-4-phenylthiazol-5-yl)-(1,1,3,3-tetramethylbutyl)amine 
• 53641-60-4 2-phenylglycinonitrile hydrochloride 
• 75-07-0 acetaldehyde 
• 54167-78-1 (1-chloro-2-oxo-2-phenyl-ethyl)-carbamic acid benzyl ester 
• 54167-92-9 (2-methyl-4-phenyl-thiazol-5-yl)-carbamic acid benzyl ester 

Downstream Products

• 1610565-88-2 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-3-(2-methyl-4-phenylthiazol-5-yl)urea 

Relevant articles and documents

THIAZOLYL AND OXAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent (1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions.

THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY

The invention provides compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A, R1, R2 and R3 are as defined in the specification; a process for their preparation; pharmaceutical compositions con