381-72-6

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluoroacetyl chloride is used as an intermediate for the synthesis of various drugs. Its acylating properties make it a valuable component in the creation of pharmaceutical compounds that may have unique therapeutic effects due to the presence of fluorine atoms.
Used in Agrochemical Production:
In the agrochemical sector, 2,2-Difluoroacetyl chloride serves as an intermediate in the production of agricultural chemicals. The incorporation of fluorine into these compounds can enhance their effectiveness and selectivity in pest control and crop protection.
Used in Chemical Synthesis:
2,2-Difluoroacetyl chloride is used as a reagent in the synthesis of fluorine-containing organic compounds. Its acylating ability is crucial for the formation of specific chemical structures that are otherwise challenging to achieve.
Used in Manufacturing of Agricultural Chemicals, Plastics, and Rubber:
2,2-Difluoroacetyl chloride is utilized in the manufacturing processes of agricultural chemicals to improve their performance, as well as in the production of plastics and rubber to enhance their properties, such as durability and resistance to environmental factors.
Safety Note:
Due to its highly corrosive and toxic nature, 2,2-Difluoroacetyl chloride requires careful handling and the implementation of stringent safety measures to prevent accidents and ensure the well-being of those who work with it.

InChI:InChI=1/C2HClF2O/c3-1(6)2(4)5/h2H

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Relevant academic research and scientific papers

PROCESS AND INTERMEDIATE FOR THE MANUFACTURE OF DIFLUOROACETYL CHLORIDE

The present invention concerns a process and intermediates for the manufacture of difluoro acetyl chloride. The invention further concerns a process for the manufacture of an agrochemically or pharmaceutically active compound, which comprises the process and intermediate for the manufacture of difluoro acetyl chloride for the manufacture of difluoro acetyl chloride or its intermediate.

Method for Producing Difluoroacetyl Chloride

A production method of difluoroacetyl chloride according to the present invention includes a chlorination step of bringing a raw material containing at least either a 1-alkoxy-1,1,2,2-tetrafluoroethane or difluoroacetyl chloride into contact with calcium chloride at a reaction enabling temperature. A production method of 2,2-difluoroethyl alcohol according to the present invention includes a catalytic reduction step of causing catalytic reduction of the difluoroacetyl chloride obtained by the above production method. By these methods, the difluoroacetyl fluoride can be efficiently converted to the difluoroacetyl chloride and to the 2,2-difluoroethyl alcohol.

TRANSFORMATION D'OXYDES D'ALKYLES ET DE POLYFLUOROALKYLES PAR LES ACIDES DE LEWIS. INFLUENCE DES RADICAUX ALKYLES.

The generation of perfluoroalkanoyl fluorides from perfluoroalkyl ethers by Lewis acids RHOCF2RF -> FRH + RFCOF depends mainly upon the nature of the alkyl RH radical.It is necessary to use RH groups with donor character and also electrophilic groups present on the radicals can facilitate the breaking of the RH-O bond.As examples, ethers with Me3SiCH2CH2 or CH2=CH-CH2 groups allowed reactions to occur readily at room temperature or below using common Lewis acids such as ZnCl2, BF3-Et2O, AlCl3.