38113-96-1

Upstream product

• 25327-36-0 (Z)-2-(hydroxyimino)-2-phenylacetic acid 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 

Downstream Products

• 39684-39-4 (Z)-methyl 2-(methoxyimino)-2-phenylacetate 
• 1408233-58-8 C₁₅H₂₃NO₃Si 
• 1408233-57-7 C₁₆H₁₅NO₅S 
• 105394-78-3 2-(N,N-diethylamino)-2-phenylacetic acid methyl ester 

Relevant academic research and scientific papers

Double nucleophilic N-alkylation of α-oxime-esters with Grignard reagents

Double nucleophilic N-alkylation of α-oxime-esters, affording N,N-dialkyl-α-amino acids is herein described. Grignard reagents accomplished double N-alkylations via umpolung and various N,N-dialkylated α-amino acids were successfully synthesized in 15 min. Both electron-withdrawing sulfonyl groups and electron-donating silyl and methyl groups on oximes were available. Alkylmagnesium species and (E)-configuration of α-oxime-ester were essential to this cascade reaction.

Caphalosporin compounds having at position-7 an α-etherified hydroxyiminoarylacetamido group

Antibiotic compounds of the general formula STR1 [wherein R is a phenyl, thienyl or furyl group; Ra and Rb, which may be the same or different, are each selected from hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-