381223-76-3Relevant academic research and scientific papers
Stereoselective and regioselective synthesis of azepane and azepine derivatives via piperidine ring expansion
Chong, Hyun-Soon,Ganguly, Bishwajit,Broker, Grant A.,Rogers, Robin D.,Brechbiel, Martin W.
, p. 2080 - 2086 (2002)
Diastereomerically pure azepane derivatives 5, 13 were prepared by piperidine ring expansion with exclusive stereoselectivity and regioselectivity and in excellent yield. The structure and stereochemistry of 5 were confirmed via X-ray crystallographic analysis. The ring expansion strategy was applied to the construction of an azepine backbone 22 of a potential biologically active compound. The regiochemistry and stereochemistry of the piperidine ring expansion process were investigated by semiempirical molecular orbital calculations.
Synthesis of DTPA analogues derived from piperidine and azepane: Potential contrast enhancement agents for magnetic resonance imaging
Chong,Garmestani,Bryant Jr.,Brechbiel
, p. 7745 - 7750 (2007/10/03)
Two DTPA derivatives (PIP-DTPA and AZEP-DTPA) as potential contrast enhancement agents in MRI are synthesized. The T1 and T2 relaxivities of their corresponding Gd(III) complexes are reported. At clinically relevant field strengths, the relaxivities of the complexes are comparable to that of the contrast agent, Gd(DTPA) which is in clinical use. The serum stability of the 153Gd-labeled complexes is assessed by measuring the release of 153Gd from the ligands. The radiolabeled Gd chelates are found to be kinetically stable in human serum for up to at least 14 days without any measurable loss of radioactivity.
