381233-96-1

Basic information

• Product Name: 2-AMINO-5-BROMO-3-IODOPYRIDINE
• Synonyms: 2-AMINO-5-BROMO-3-IODOPYRIDINE;5-BROMO-3-IODO-PYRIDIN-2-YLAMINE;2-Amino-3-iodo-5-bromopyridine;5-Bromo-3-iodopyridin-2-amine;2-Amine-5-bromo-3-iodopyridine;5-Bromo-3-iodo-2-pyridinamine;2-PyridinaMine,5-broMo-3-iodo-;5-Bromo-3-iodo-2-aminopyridine
• CAS NO: 381233-96-1
• Molecular Formula: C₅H₄BrIN₂
• Molecular Weight: 298.91
• Product Categories: pharmacetical;Amines;pyridine;Building Blocks;C5;C5 to C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 381233-96-1.mol
• Article Data: 32

Chemical Properties

• Melting Point: 111-112°C
• Boiling Point: 308.2 °C at 760 mmHg
• Flash Point: 140.2 °C
• Appearance: Brown powder
• Density: 2.426 g/cm³
• Vapor Pressure: 0.000691mmHg at 25°C
• Refractive Index: 1.73
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.25±0.49(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-AMINO-5-BROMO-3-IODOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMO-3-IODOPYRIDINE(381233-96-1)
• EPA Substance Registry System: 2-AMINO-5-BROMO-3-IODOPYRIDINE(381233-96-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36:37/38-41-37/38-22
• Safety Statements: 26-36/37/39-37
• WGK Germany: 3
• HazardClass: IRRITANT, LIGHT SENSITIVE
• Hazardous Substances Data: 381233-96-1(Hazardous Substances Data)

Usage

Chemical Properties

Brown powder

InChI:InChI=1/C5H4BrIN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

Upstream product

• 504-29-0 2-aminopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 104830-06-0 3-iodo-2-aminopyridine 
• 875639-47-7 C₉H₈BrIN₂O₂ 

Downstream Products

• 381233-75-6 5-bromo-3-iodo-1,2-dihydropyridin-2-one 
• 1314883-32-3 5-[3-fluoro-4-(methylsulfonyl)phenyl]-3-(2-methoxypyridin-5-yl)pyridin-2-amine 
• 1314883-43-6 2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl-5-boronic acid 
• 953414-71-6 5-bromo-3-(phenylethynyl)pyridin-2-amine 
• 1612287-97-4 5-bromo-3-[(2-chloro-6-fluorophenyl)ethynyl]pyridin-2-amine 
• 1443684-80-7 5-bromo-2-(2-chloro-6-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine 
• 1621887-63-5 2-(4-fluorophenyl)-5-(11-fluoropyrido[2',3':4,5]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1449299-72-2 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide 
• 1449299-70-0 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-(2-fluoroethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-69-7 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-67-5 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,4-dihydropyridine-3-carboxamide 
• 1449299-66-4 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-(2-methoxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-65-3 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(propan-2-yl)-1,4-dihydropyridine-3-carboxamide 

Relevant articles and documents

SUBSTITUTED (AZA)INDOLE DERIVATIVES

The invention relates to substituted (aza)indole derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing them and to their use as modulators of α7 nicotinic acetylcholine receptor activity in a mammalian subject. (I)

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.