38127-47-8Relevant articles and documents
A colorimetric and near-infrared ratiometric fluorescent probe for hydrazine detection and bioimaging
Li, Haitao,Li, Yaqian,Pang, Xiao,Wu, Cuiyan,Xie, Ruihua,Zhou, Zile
, (2020)
Hydrazine (N2H4) is extensively used in industry but highly toxic; hence, highly sensitive detection of N2H4 is extremely meaningful. Herein, a colorimetric and near-infrared (NIR) ratiometric fluorescent probe
Domino synthesis of the ABC tricyclic core of strigolactones and analogues
Le Floch, Camille,Sengmany, Stéphane,Le Gall, Erwan,Léonel, éric
, p. 331 - 342 (2013)
The diversity-oriented synthesis of the ABC tricyclic core of strigolactones and analogues is described starting from ortho-halogenated aromatic or vinylic carbonyl compounds and dimethyl itaconate. It involves a conjugate addition/aldol coupling/lactoniz
Development of a novel NIR viscosity fluorescent probe for visualizing the kidneys in diabetic mice
Dai, Lixuan,Ren, Mingguang,Lin, Weiying
, (2021)
Viscosity is an important parameter for evaluating cell health, and abnormal viscosity can cause a variety of intracellular organelle function disorders. The mitochondria are a key organelle in cells, and the viscosity of the mitochondria determines the s
Discriminative detection of cysteine/homocysteine and glutathione in HeLa cells by dual-channel fluorescent probe
Chen, Yu,Wang, Yumin,Wu, Xiang Hua,Liu, Bo,Zhang, Jun Feng
, (2021)
Biothiols such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) play important roles in various physiological and pathological processes. However, it is still a great challenge to selectively detect Cys/Hcy and GSH in biological samples due to
Introducing cyclic alkyl chains into small-molecule acceptors for efficient polymer solar cells
Li, Renlong,Liu, Gongchu,Xie, Ruihao,Wang, Zhenfeng,Yang, Xiye,An, Kang,Zhong, Wenkai,Jiang, Xiao-Fang,Ying, Lei,Huang, Fei,Cao, Yong
, p. 7046 - 7053 (2018)
A new acceptor-donor-acceptor type small molecule acceptor, namely IDT-HN, has been developed, which consists of a newly developed 2-(3-oxo-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-ylidene)malononitrile as the peripheral electron-withdrawing gro
A novel near-infrared fluorescent probe for detecting intracellular alkaline phosphatase and imaging of living cells
Xu, Longbin,He, Xu,Huang, Yibing,Ma, Pinyi,Jiang, Yanxiao,Liu, Xin,Tao, Shuo,Sun, Ying,Song, Daqian,Wang, Xinghua
, p. 1284 - 1291 (2019)
Development of novel near-infrared (NIR) fluorescent probes for the monitoring of active substances in living organism is desirable in biological studies. Herein, we designed a novel NIR MTR fluorophore which has a longer emission wavelength, greater Stok
Palladium-catalyzed alkoxycarbonylation of conjugated enyne oxiranes: A diastereoselective method for the synthesis of 7-hydroxy-2,3,5-trienoates
Ku?, Melih,Artok, Levent,Aygün, Muhittin
, p. 5494 - 5506 (2015)
Palladium-catalyzed alkoxycarbonylative 1,5-substitution of conjugated enyne oxiranes provides a diastereoselective route to (E)-configured 7-hydroxy-2,3,5-trienoates. The reactions proceeded in a highly stereoselective manner, possibly through sequential
Design and synthesis of pH-sensitive fluorescently-labeled anti-tumor prodrug
-
Paragraph 0016, (2021/04/28)
The invention discloses a preparation method of a pH-sensitive fluorescently-labeled anti-tumor prodrug, and the structure of the prodrug is as shown in the formula.
Synthesis of illudalic acid and analogous phosphatase inhibitors
Ahmed, Kh Tanvir,Barrios, Amy M.,Batsomboon, Paratchata,Dudley, Gregory B.,Fulo, Harvey F.,Gaston, Robert,Rueb, Nicole J.
supporting information, p. 10596 - 10600 (2021/12/27)
Developing an efficient, concise synthesis of the fungal natural product illudalic acid has been a long-standing challenge, made more pressing by the recent discovery that illudalic acid and analogs are selective phosphatase inhibitors. Syntheses of illudalic acid have become progressively more efficient over the decades yet remain strategically grounded in a 17-step synthesis reported in 1977. Here we validate a two-step process—convergent [4 + 2] benzannulation and one-pot coordinated functional group manipulations—for preparing the key trifunctional pharmacophore of illudalic acid. The modular building blocks are readily available in 2-3 steps, for a longest linear sequence (LLS) of 5 steps to illudalic acid from 3,3-dimethylcyclopentanone. A small collection of analogous indanes and tetralins featuring the same pharmacophore were prepared by a similar route. These compounds potently and selectively inhibit the human leukocyte common antigen-related (LAR) subfamily of protein tyrosine phosphatases (PTPs). Evidence supporting a postulated covalent ligation mechanism is provided herein.
