38127-55-8

Usage

Uses

Used in Pharmaceutical Synthesis:
(2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form diverse chemical bonds and contribute to the development of new drug molecules.
Used in Agrochemical Synthesis:
In the agrochemical industry, (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine is utilized as a building block for the creation of various agrochemicals, such as pesticides and herbicides, due to its reactivity and potential to enhance the effectiveness of these products.
Used in Organic Chemistry Research:
(2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine serves as a valuable compound in organic chemistry research, where it is employed to explore new reaction pathways and develop innovative synthetic methods.
It is important to handle (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine with care, as it can be hazardous if not properly managed.

Upstream product

• 64-17-5 ethanol 
• 555-16-8 4-nitrobenzaldehdye 
• 60-34-4 methylhydrazine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 38127-54-7 5,5-Dimethyl-3-{N-methyl-N'-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-hydrazino}-cyclohex-2-enone 
• 40093-40-1 C₁₃H₁₈N₄O₂S 
• 135676-88-9 1-Methyl-3-(4-nitro-phenyl)-4,6-diphenyl-1,2,3,4-tetrahydro-[1,2,4,5]tetrazine 
• 134122-68-2 1-methyl-3-(p-nitrophenyl)-5-(D-galacto-pentitol-1-yl)pyrazole 
• 134122-60-4 1-methyl-3-(p-nitrophenyl)-5-(1,2,3,4,5-penta-O-acetyl-D-galacto-pentitol-1-yl)pyrazole 
• 134122-57-9 p-nitrobenzaldehyde N-methyl-N-(3,4,5,6,7-penta-O-acetyl-1,2-dideoxy-1-nitro-D-galacto-heptitol-2-yl)hydrazone 
• 135701-11-0 C₁₇H₁₇N₅O₄ 
• 64643-24-9 (2E)-3-[1-methyl-2-(4-nitro-benzylidene)-hydrazino]-crotonic acid ethylester 
• 41555-57-1 3-{N-Methyl-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-cyclohex-2-enone 
• 41555-77-5 2-Methyl-3-{N-methyl-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-cyclopent-2-enone 
• 1016169-46-2 1-methyl-3-(4-nitro-phenyl)-4-p-tolyl-1H-pyrazole 
• 1014625-54-7 1-methyl-3-(4-nitro-phenyl)-5-p-tolyl-1H-pyrazole 
• 43131-48-2 4,1,20.2-methyl-5-(4-nitrophenyl)-2H-tetrazole 
• 1608493-82-8 1-methyl-4-nitro-3-(4-nitrophenyl)-5-phenyl-1H-pyrazole 

Relevant academic research and scientific papers

Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3d cell culture systems

Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts.

Acid-Mediated Three Component Assembly of 4-Fluoropyrazoles from α-Fluoronitroalkenes, Hydrazines, and Aldehydes

A new approach for the synthesis of highly pharmaceutically relevant 4-fluoropyrazoles via oxidative annulation of α-fluoronitroalkenes with in situ prepared hydrazones was developed. The reaction is efficiently promoted by trifluoroacetic acid while atmo

Preparation of 5-Aryl-2-Alkyltetrazoles with Aromatic Aldehydes, Alkylhydrazine, Di-tert-butyl Azodicarboxylate, and [Bis(trifluoroacetoxy)iodo]benzene

A variety of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles were directly prepared in good to moderate yields by the reaction of aromatic aldehydes with methylhydrazine and benzylhydrazine, followed by treatment with di-tert-butyl azodicarboxylate and [bis(trifluoroacetoxy)iodo]benzene in a mixture of dichloromethane and 2,2,2-trifluoroethanol at room temperature. The present method is a novel one-pot preparation of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles through a [2N + 2N] combination under transition metal-free and mild conditions.

Regioselective Synthesis of 4-Nitro- or 4-Chloro-Tetrasubstituted Pyrazoles from Hydrazones and β-Halo-β-nitrostyrenes

We report an acid-catalyzed cycloaddition reaction of hydrazones with β-bromo- or β-chloro-β-nitrostyrenes for the regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles. Arising from a common 4-halo-4-nitropyrazolidine intermediate,

Regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles from hydrazones and β-halo-β-nitrostyrenes

We report an acid-catalyzed cycloaddition reaction of hydrazones with β-bromo- or β-chloro-β-nitrostyrenes for the regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles. Arising from a common 4-halo-4-nitropyrazolidine intermediate,

Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: A novel synthesis of 1,3,4-Trisubstituted pyrazoles

A regioselective synthesis of 1,3,4-tri- or 1,3,4,5-tetrasubstituted pyrazoles by the reaction of hydrazones with nitroolefins is described. Mediated with strong bases such as t-Bu OK, the reaction exhibits a reversed, exclusive 1,3,4-regioselectivity. Su