38150-49-1

Usage

Uses

Used in Pharmaceutical Industry:
DL-ALPHA-(3-THIENYL)GLYCINE is used as a building block for the synthesis of various drugs and pharmaceuticals, contributing to the development of new therapeutic agents.
Used in Medicinal Chemistry:
DL-ALPHA-(3-THIENYL)GLYCINE is used as a precursor in the development of new drugs, particularly for the treatment of neurological disorders, due to its potential to influence specific biological pathways and mechanisms.
Used in Material Science:
DL-ALPHA-(3-THIENYL)GLYCINE is used as an ingredient in the development of novel materials, leveraging its unique chemical properties to create innovative substances with specialized applications.
Used in Agrochemical Production:
DL-ALPHA-(3-THIENYL)GLYCINE is used as a component in the production of agrochemicals, where it may contribute to the formulation of new pesticides, herbicides, or other agricultural products to enhance crop protection and yield.

Upstream product

• 97101-16-1 (2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure 
• 97036-30-1 (2R)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure 
• 97036-26-5 (2R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(3-thienyl)acetonitril 
• 498-62-4 3-thiophene carboxaldehyde 
• 97036-28-7 (2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(3-thienyl)acetonitril 
• 97036-24-3 (4S,5S)-(+)-2,2-Dimethyl-4-phenyl-5-<(3-thienylmethylen)amino>-1,3-dioxan 

Downstream Products

• 73-32-5 DL-isoleucine 
• 126823-63-0 N-<(o-nitrophenyl)sulfenyl>-D,L-3-thienylglycine (+)-β-fenchyl ester 
• 1183538-72-8 2-amino-2-(thiophen-3-yl)ethan-1-ol 
• 891789-94-9 C₁₃H₁₁ClN₂O₃S 
• 40512-57-0 (±)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid 
• 470670-70-3 2,5-dioxo-4-thiophen-3-yl-oxazolidine-3-carboxylic acid benzyl ester 
• 126823-57-2 N-<(o-nitrophenyl)sulfenyl>-D,L-3-thienylglycine 

Relevant academic research and scientific papers

Nonproteinogenic Amino Acids, III. - Syntheses of the Enantiomerically Pure 2-(2-Thienyl)- and 2-(3-Thienyl)glycines. - Molecular Structure of the Intermediate Schiff's Bases

The syntheses of enantiomerically pure D-(-)- and L-(+)-2-(2-thienyl)- and 2-(3-thienyl)glycines (6a-d) are described.Preparing the amino nitriles 4 directly from 2-thiophenecarbaldehyde (1a) or 3-thiophenecarbaldehyde (1b), respectively, and (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (2), and hydrocyanic acid (one-step procedure), the aminonitriles 4a and 4b, respectively, are formed in excess.By crystallization they are obtained diastereomerically pure leading to enantiomerically pure D-amino acids 6a and 6b.If, however, the intermediate Schiff's bases 3 are isolated as crystals and then converted with hydrocyanic acid into the respective aminonitriles 4 (two-step procedure), the diastereomeric aminonitriles 4c and 4d, respectively, crystallize resulting in enantiomerically pure L-amino acids 6a and 6d.X-ray structure analyses of the Schiff's bases 3c and 3e revealed the previously postulated E-configuration of the C=N bond and its chiral shielding by the phenyl substituent at C4.