3816-66-8

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 3-hydroxy-4-methylis used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of drug molecules, making it a valuable component in the development of new medications.
Used in Synthetic Resins Industry:
In the production of synthetic resins, Benzonitrile, 3-hydroxy-4-methylis used as a key ingredient. Its chemical properties contribute to the formation of resins with specific characteristics, such as durability and resistance to various environmental factors.
Used in Dyes Production:
Benzonitrile, 3-hydroxy-4-methylis used as a starting material in the synthesis of various dyes. Its presence in the dye molecules can influence the color, stability, and other properties of the final product, making it an essential component in the dye industry.
Safety Measures:
Due to its potential for causing skin and eye irritation, and negative impacts if inhaled or ingested, Benzonitrile, 3-hydroxy-4-methylshould be handled with adequate safety measures. Proper protective equipment, such as gloves and goggles, should be worn during handling, and the substance should be stored in a well-ventilated area to minimize the risk of exposure.

InChI:InChI=1/C8H7NO/c1-6-2-3-7(5-9)4-8(6)10/h2-4,10H,1H3

Upstream product

• 2362-12-1 4-Bromo-2-methylphenol 
• 42872-74-2 3-bromo-4-methyl-benzonitrile 
• 1188374-87-9 3-benzyloxy-4-methyl-benzonitrile 
• 104-85-8 para-methylbenzonitrile 
• 939-79-7 4-cyano-2-nitrotoluene 
• 60710-80-7 5-cyano-2-methylaniline 
• 7577-74-4 6-acetoxy-6-methylcyclohexa-2,4-dienone 
• 151-50-8 potassium cyanide 

Downstream Products

• 3556-60-3 3-methoxy-4-methylcyano-benzene 
• 84102-94-3 <(6-Cyan-2-benzofuran-2-yl)methyl>triphenylphosphoniumchlorid 
• 84223-47-2 4',6-Bis(2-imidazolin-2-yl)-1-benzofuran-2-carboxanilid-dihydrochlorid 
• 84223-86-9 2-<2-(6-Amidino-1-benzofuran-2-yl)ethyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84223-79-0 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84103-01-5 6-Amidino-N-(4-amidinophenyl)-1-benzofuran-2-carboxamid-dihydrochlorid 
• 84103-00-4 6-Cyan-N-(4-cyanphenyl)-1-benzofuran-2-carboxamid 
• 84102-88-5 3-Acetoxy-4-(dibrommethyl)benzonitril 
• 84102-89-6 4-formyl-3-hydroxybenzonitrile 
• 84102-87-4 5-cyano-2-methylphenyl acetate 
• 92705-79-8 3-Hydroxy-4-methyl-benzylamin 
• 873999-89-4 5-hydroxy-4-methyl-2-nitro-benzonitrile 
• 586-30-1 3-hydroxy-4-methylbenzoic acid 

Relevant academic research and scientific papers

Pd2dba3/Bippyphos: A robust catalyst system for the hydroxylation of aryl halides with broad substrate scope

A mixture of tris(dibenzylideneacetone)dipalladium(0) (Pd 2dba3) and 5-(di-tert-butylphosphino)-1′,3′, 5′-triphenyl-1′H-[1,4′]bipyrazole (Bippyphos) is shown to be a robust and efficient catalyst system for the hydroxylation of structurally diverse (hetero)aryl halides under mild conditions and with broad substrate scope. Included in this reactivity survey is the successful synthesis of substituted benzofurans and related heteroatomic derivatives, which are formed via the hydroxylation of 2-haloalkynylarenes. Notably, a significant number of the reactions reported herein proceed at room temperature, and we have demonstrated that it is possible to conduct reactions on the benchtop under air using unpurified solvents with negligible loss in reactivity versus related transformations conducted under inert atmosphere conditions. We also report herein the first crystallographically characterized (Bippyphos)Pd(II) complex, which confirms the ability of this synthetically useful ligand to adopt a bidentate binding motif in a manner similar to Buchwald's biarylphosphine ligand class. Copyright

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.

Thrombin inhibitors, the preparation and use thereof

Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

Chalcone derivatives and drugs containing the same

PCT No. PCT/JP97/01652 Sec. 371 Date Nov. 17, 1998 Sec. 102(e) Date Nov. 17, 1998 PCT Filed May 16, 1997 PCT Pub. No. WO97/44306 PCT Pub. Date Nov. 27, 1997This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the like, and R1 to R5 each independently represent a carboxyl, cyano, alkyloxycarbonyl or like group, or salts of the chalcone derivatives, and also to drugs containing them as effective ingredients. These compounds have excellent cys-LT receptor antagonism, and are useful as antiallergic agents or the like.

Thrombin inhibitors

Thrombin inhibitors of the formula STR1 where R 1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described.The compounds I are suitable for controlling diseases.