381691-45-8

Upstream product

• 381691-42-5 methyl 4-[2-(2-chloro-3-cyanopyrid-4-yl)ethyl]benzoate 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 381691-43-6 methyl 4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoate 
• 381691-41-4 methyl 4-[4,4-dicyano-3-(2-dimethylaminovinyl)but-3-enyl]benzoate 

Downstream Products

• 381691-48-1 diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate 

Relevant academic research and scientific papers

Synthesis of 5-substituted pyrido[2,3-d]pyrimidines as analogues of the antifolates methotrexate, DDATHF and pemetrexed (LY231514)

The preparation of 5-substituted pyrido[2,3-d]pyrimidines (18,19,21) as analogues of the antifolates methotrexate (1), DDATHF (2) and pemetrexed (LY231514) (3) is outlined, starting from methyl 4-(3-oxobutyl)benzoate (4). Key steps involve high yielding K