38176-01-1

Basic information

• Product Name: (2R)-(+)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
• Synonyms: (2R)-(+)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
• CAS NO: 38176-01-1
• Molecular Weight: 295.809
• Mol File: 38176-01-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R)-(+)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-(+)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile(38176-01-1)
• EPA Substance Registry System: (2R)-(+)-5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile(38176-01-1)

Safety Data

• Hazardous Substances Data: 38176-01-1(Hazardous Substances Data)

Upstream product

• 36770-70-4 (2R)-(+)-2-(3,4-dimethoxyphenyl)-5-hydroxy-2-isopropylpentanenitrile 
• 58139-65-4 2-(3,4-Dimethoxyphenyl)-2-isopropyl-methylpent-4-enonat 
• 58139-64-3 2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 349078-92-8 (4E,3S)-(+)-3-(3,4-dimethoxyphenyl)-3-isopropylhex-4-enyl tosylate 
• 349078-91-7 (4E,3R)-(-)-3-(3,4-dimethoxyphenyl)-3-isopropylhex-4-enyl tosylate 
• 349079-02-3 (5E,4S)-(+)-4-(3,4-dimethoxyphenyl)-4-isopropylhept-5-enyl acetate 
• 349079-01-2 (5E,4R)-(-)-4-(3,4-dimethoxyphenyl)-4-isopropylhept-5-enyl acetate 
• 255721-22-3 (4R)-(+)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl acetate 
• 349078-96-2 (5E,4S)-(+)-4-(3,4-dimethoxyphenyl)-4-isopropylhept-5-enoic acid 
• 349078-95-1 (5E,4R)-(-)-4-(3,4-dimethoxyphenyl)-4-isopropylhept-5-enoic acid 
• 349079-04-5 (4R)-(+)-4-(3,4-dimethoxyphenyl)-4-formyl-5-methylhexyl acetate 
• 349079-03-4 (4S)-(-)-4-(3,4-dimethoxyphenyl)-4-formyl-5-methylhexyl acetate 
• 349078-98-4 methyl (5E,4S)-(+)-4-(3,4-dimethoxyphenyl)-4-isopropylhept-5-enoate 

Downstream Products

• 38321-02-7 dexverapamil 

Relevant articles and documents

Enzyme-mediated synthesis of (S)- And (R)-verapamil

A lipase-mediated synthesis of (S)- And (R)-verapamil is described. The key steps of the synthetic sequence are the enantioselective acetylation, mediated by Lipase PS, of allylic alcohol (Z)-(±)-2, affording the acetate derivative (Z,R)-(-)-3 (ee 92%) and the Ireland-Claisen rearrangement of this latter and of its enantiomer (Z,S)-(+)-3 (ee 92%) to afford acid derivatives (E,R)-(-)-4 (ee 94%) and (E,S)-(+)-4 (ee 93%), precursors of (S)- and (R)-verapamil, respectively.