3818-16-4

Usage

Uses

Used in Organic Synthesis:
1-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-yl)triaza-1,2-dien-2-ium is used as a synthetic intermediate for the development of various organic compounds. Its unique molecular structure allows for the creation of a wide range of chemical products, contributing to the advancement of organic chemistry.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-yl)triaza-1,2-dien-2-ium is used as a potential candidate for the development of new drugs. Its complex molecular structure may offer novel therapeutic properties, providing opportunities for the treatment of various medical conditions.
Used in Pharmaceutical Industry:
1-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-yl)triaza-1,2-dien-2-ium is used as a key component in the pharmaceutical industry for the synthesis of innovative drugs. Its unique properties and potential applications make it a valuable asset in the development of new medications to address unmet medical needs.
Used in Research and Development:
1-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-yl)triaza-1,2-dien-2-ium is also utilized in research and development settings, where scientists and chemists explore its properties, reactivity, and potential applications. The findings from these studies can lead to a better understanding of the compound's capabilities and its integration into various industries, including pharmaceuticals, materials science, and chemical engineering.

Upstream product

• 3817-96-7 2-chloro-2-phenyl-1,3-indandione 
• 83-12-5 phenindione 

Downstream Products

• 23994-23-2 3-phenyl-isoquinoline-1,4-dione 
• 100-47-0 benzonitrile 
• 6383-11-5 benzocyclobutene-1,2-dione 

Relevant academic research and scientific papers

Sulfonium ion-promoted traceless Schmidt reaction of alkyl azides

Schmidt reaction by sulfonium ions is described. General primary, secondary, and tertiary alkyl azides were converted to the corresponding carbonyl or imine compounds without any trace of the activators. This bond scission reaction through 1,2-migration of C-H and C-C bonds was accessible to the one-pot substitution reaction.

Photoinduced α-Cleavage of 2-Azido-2-phenyl-1,3-indandione at Cryogenic Temperatures

To expand the utility of α-cleavage at cryogenic temperatures, we investigated the photoreactivity of 2-azido-2-phenyl-1,3-indandione (1). EPR spectroscopy revealed that irradiating 1 in 2-methyltetrahydrofuran (mTHF) matrices forms alkylnitrene 32, which has zero-field splitting parameters (D/hc = 1.5837 cm-1 E/hc = 0.0039 cm-1) typical of an alkylnitrene. IR spectroscopy demonstrated that irradiating 1 in argon matrices results in the concurrent formation of 32, imine 3, benzocyclobutenedione 4, and benzonitrile 5.

Ring Expansion of 2-Azido-2-phenyl-indan-1,3-dione for the Generation of Heterocyclic Scaffolds

A novel ring expansion based on the readily available 2-azido-2-phenyl-indan-1,3-dione is described. Treatment with primary amines and cesium carbonate in a two-step sequence gives rise to 3-amino-2,3-dihydroisoquinoline-1,4-diones with an unprecedented substitution pattern. The corresponding conversion using amino acid methyl esters leads directly to a novel tricyclic 1,10a-dihydroimidazo-isoquinoline-2,5,10-trione scaffold, a structure that has never been reported before, to the best of our knowledge.