3818-50-6 Usage
Pharmacology and mechanism of action
Bephenium is a quaternary ammonium compound first introduced into clinical medicine in 1958. It has a wide anthelminthic activity, in particular against Ancylostoma duodenale and Ascaris lumbricoides.
The mechanism of action of bephenium is similar to that of pyrantel and levamisole (see the monograph on levamisole, p. 74).
Indications
Different sources of media describe the Indications of 3818-50-6 differently. You can refer to the following data:
1. Infections with Ancylostoma duodenale, Ascaris lumbricoides and Necator americanus. Superior alternative drugs are available today.
2. This drug exhibits antihelmintic action by acting as a cholinergic agonist, causing paralysis
of the parasite musculature. This facilitates its removal from the intestines. It is used for
treating ascariasis, ankylostomiasis, enterobiasis, trichostrongyliasis, and tricocefalosis. A
single dose of bephenium heals from 80 to 100% of patients infected with A. duodenale. It
is less effective with respect to N. americanus. Synonyms of this drug are aclopar and
others.
Side effects
The drug has a bitter taste which might cause some patients especially children to refuse intake or vomit. This may be minimized by giving the drug with a sweet drink. Some individuals experience transient nausea, vomiting and headache after drug intake. Vertigo is occasionally reported.
Contraindications
There are no known contraindications to the drug.
Interactions
Bephenium has antagonistic effects to piperazine. However, no interactions were reported when the two drugs were combined together during helminthic therapy [1].
Preparations
5 g bephenium hydroxynaphthoate contains 2.9 g bephenium.
? Alcopar? (Wellcome). Sachet containing 5 g of bephenium hydroxynaphthoate.
References
1. Goodwin LG, Jayewardene LG, Standen OD (1958). Clinical trials with bephenium hydroxynaphthoate against hookworm in Ceylon. BMJ, 2, 1572–1576.
Uses
Different sources of media describe the Uses of 3818-50-6 differently. You can refer to the following data:
1. antibacterial, antilepretic, antituberculosis
2. Bephenium Hydroxynapthoate is an anthelmintic agent used to treat hookworm infections and ascariasis.
Synthesis
Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl)
ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid
with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made
from benzyl chloride and N-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride.
Check Digit Verification of cas no
The CAS Registry Mumber 3818-50-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,1 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3818-50:
(6*3)+(5*8)+(4*1)+(3*8)+(2*5)+(1*0)=96
96 % 10 = 6
So 3818-50-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H22NO.C11H8O3/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17;12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h3-12H,13-15H2,1-2H3;1-6,12H,(H,13,14)/q+1;/p-1
