382138-99-0

Upstream product

• 101224-43-5 6-(trimethylsilyl)hex-5-ynoic acid: 
• 121074-21-3 (2S)-2-ethyl-4-penten-1-ol 
• 382139-20-0 (S)-2-Methyl-6-trimethylsilanyl-hex-5-yn-1-ol 
• 382139-21-1 (S)-2-Methyl-6-trimethylsilanyl-hex-5-ynal 
• 382139-15-3 (5S,6S,8S,9S,10S,11S,12S,13S,15S)-15-(tert-Butyl-diphenyl-silanyloxymethyl)-10-(4-methoxy-benzyloxy)-5,9,11,13-tetramethyl-12-triethylsilanyloxy-1-trimethylsilanyl-heptadec-1-yne-6,8-diol 
• 382139-14-2 (4S,6S)-4-[(1S,2S,3S,4S,5S,7S)-7-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-1,3,5-trimethyl-4-triethylsilanyloxy-nonyl]-2,2-dimethyl-6-((S)-1-methyl-5-trimethylsilanyl-pent-4-ynyl)-[1,3]dioxane 
• 382138-93-4 (5S,8S,9S,10S,11S,12S,13S,15S)-15-(tert-Butyl-diphenyl-silanyloxymethyl)-8-hydroxy-10-(4-methoxy-benzyloxy)-5,9,11,13-tetramethyl-12-triethylsilanyloxy-1-trimethylsilanyl-heptadec-1-yn-6-one 
• 382139-17-5 2,2-Dimethyl-propionic acid (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonyl ester 
• 382139-13-1 (2S,3S,4S,5S,6S,8S)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-5-triethylsilanyloxy-decan-1-ol 
• 382138-97-8 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonanoic acid methyl ester 
• 382139-18-6 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonanoic acid amide 
• 382138-90-1 (2S,4S,5S)-4-[(1S,2S,3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1,3-dimethyl-2-triethylsilanyloxy-heptyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane 
• 382138-96-7 (2S,4S,5S,6S,7S,8S)-8-[(4S,6S)-2,2-Dimethyl-6-((S)-1-methyl-pent-4-ynyl)-[1,3]dioxan-4-yl]-2-ethyl-7-(4-methoxy-benzyloxy)-4,6-dimethyl-5-triethylsilanyloxy-nonan-1-ol 
• 382138-91-2 (2R,3R,4S,5S,6S,8S)-8-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-5-triethylsilanyloxy-decanal 

Relevant academic research and scientific papers

A convergent three-component total synthesis of the powerful immunosuppressant (-)-sanglifehrin A

The potent immunosuppressive agent (-)-sanglifehrin A (5), initially discovered in a soil sample from Malawi, has been synthesized in a highly conver soil gent and stereocontrolled manner. The enantioselective approach relies on initial construction of th

Enantioselective total synthesis of the cyclophilin-binding immunosuppressive agent sanglifehrin A

Crafting of the building blocks 1-3 allows the convergent conjoining of 2-3 in advance of macrolactonization. The subsequent linkup of the eastern sector with 1 by Stille coupling enabled the convenient stereocontrolled assembly of the immunosuppressive a