382150-78-9

Basic information

• Product Name: di-tert-butyl 2-(2-amino-4-fluorophenyl)malonate
• Synonyms: di-tert-butyl 2-(2-amino-4-fluorophenyl)malonate
• CAS NO: 382150-78-9
• Molecular Weight: 325.38
• Mol File: 382150-78-9.mol

Chemical Properties

• CAS DataBase Reference: di-tert-butyl 2-(2-amino-4-fluorophenyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl 2-(2-amino-4-fluorophenyl)malonate(382150-78-9)
• EPA Substance Registry System: di-tert-butyl 2-(2-amino-4-fluorophenyl)malonate(382150-78-9)

Safety Data

• Hazardous Substances Data: 382150-78-9(Hazardous Substances Data)

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 541-16-2 t-butyl malonate 
• 382150-76-7 di-tert-butyl 2-(4-fluoro-2-nitrophenyl)malonate 

Downstream Products

• 382150-80-3 2-[2-(1-benzyloxycarbonyl-piperidin-4-ylamino)-4-fluoro-phenyl]-malonic acid di-tert-butyl ester 
• 382150-82-5 4-(6-fluoro-2-oxo-2,3-dihydro-indol-1-yl)-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF-176

Compounds of Formula 1, or pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, n, m, and p are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

A short and efficient synthesis of N-substituted indol-2-ones (oxindoles)

A short and high yielding process has been developed for the synthesis of N-(4-piperidinyl)-indol-2-ones. This strategy also constitutes a general route to N-substituted indol-2-ones.