382179-68-2Relevant academic research and scientific papers
Unexpected formation of 4-aryl-3-cyano-6-phenylpyridine-2(1H)-thiones from the reaction of arylmethylenecyanothioacetamides with benzoyl-1,1,1- trifluoroacetone
Dyachenko,Chernega
, p. 1499 - 1506 (2007/10/03)
4-Aryl-3-cyano-6-phenylpyridine-2(1H)-thiones, used in the synthesis of substituted 2-alkylthiopyridines, thieno[2,3-b]pyridines, and 1,4-di(pyridin-2-ylthio)butane, have been synthesized by the condensation of arylmethylenecyanothioacetamides with benzoyl-1,1,1-trifluoroacetone. The reaction path includes the formation of the Michael adduct which undergoes loss of the acyl group. The structure of 3-cyano-2-methylthio-4-(1-naphthyl)-6- phenylpyridine has been studied by X-ray crystallography. 2005 Springer Science+Business Media, Inc.
Reactions of cyanothioacetamide: Synthesis of several new thioxohydro-pyridine-3-carbonitrile and thieno[2,3-b]pyridine derivatives
Attaby, Fawzy A.,Eldin, Sanaa M.,Elneairy, Mohamed A. A.,El-Louh, Ali K. K.
, p. 2205 - 2220 (2007/10/03)
Cyanothioacetamide (1) reacted with α,β-unsaturated carbonyl compounds 2a-d to afford thioxohydropyridine-3-carbonitriles 5a-d, which were used as the starting materials for the preparation of several thienopyridines via their reactions with active halogen-containing compounds, e.g., 2-bromo-1-phenylethanone (7a), 2-bromo-1-p-tolylethanone (7b), chloroacetone (10a), α-chloroacetylacetone (10b), and chloroacetic acid ethyl ester (13). The structure of the newly synthesized heterocyclic compounds were established based on the data of elemental analyses, IR, 1H NMR, and mass spectra.
