38218-77-8 Usage
Description
Cyanocobalamin-b-monocarboxylic acid, a derivative of Vitamin B12, is a water-soluble vitamin that plays a crucial role in the normal functioning of the brain and nervous system, as well as in the formation of blood. It is essential for maintaining overall health and well-being.
Uses
Used in Pharmaceutical Industry:
Cyanocobalamin-b-monocarboxylic acid is used as a therapeutic agent for treating various health conditions related to Vitamin B12 deficiency. It is particularly effective in addressing issues such as megaloblastic anemia, neurological disorders, and cognitive impairments caused by a lack of this vital nutrient.
Used in Nutritional Supplements:
In the dietary supplement industry, cyanocobalamin-b-monocarboxylic acid is used as an additive to enhance the nutritional value of products, ensuring that individuals receive adequate amounts of Vitamin B12 to support their brain, nervous system, and blood formation.
Used in Functional Foods:
Cyanocobalamin-b-monocarboxylic acid is also utilized in the development of functional foods, which are designed to provide health benefits beyond their basic nutritional value. These foods may include fortified cereals, energy bars, and beverages that target specific health concerns, such as cognitive function and energy levels.
Used in Cosmetics:
In the cosmetics industry, cyanocobalamin-b-monocarboxylic acid is used as an ingredient in skincare and hair care products due to its potential benefits for skin health and hair growth. It may be included in formulations to promote skin regeneration, reduce inflammation, and improve overall skin and hair condition.
Overall, cyanocobalamin-b-monocarboxylic acid is a versatile compound with applications in various industries, primarily due to its role in maintaining the health of the brain, nervous system, and blood. Its use in pharmaceuticals, nutritional supplements, functional foods, and cosmetics highlights its importance in promoting overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 38218-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,2,1 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38218-77:
(7*3)+(6*8)+(5*2)+(4*1)+(3*8)+(2*7)+(1*7)=128
128 % 10 = 8
So 38218-77-8 is a valid CAS Registry Number.
38218-77-8Relevant articles and documents
Structures of the b- and d-acid derivatives of vitamin B12 and their complexes with [M(CO)3]+ (M = 99mTc, Re)
Spingler, Bernhard,Mundwiler, Stefan,Ruiz-Sanchez, Pilar,Van Staveren, Dave R.,Alberto, Roger
, p. 2641 - 2647 (2007)
The acid hydrolysis of natural vitamin B12 yields several products in which the acetamide or propionamide side chains on the corrin framework are converted into the corresponding acids. These acids can be derivatised with further functionalitie
Conjugation of a novel histidine derivative to biomolecules and labelling with [99mTc(OH2)3(CO)3]+.
van Staveren, Dave R,Mundwiler, Stefan,Hoffmanns, Ulrich,Pak, Jae Kyoung,Spingler, Bernhard,Metzler-Nolte, Nils,Alberto, Roger
, p. 2593 - 2603 (2008/10/09)
The new histidine derivative 3-[1-[3-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]-1H-imidazol-4-yl]-2-(3-trimethylsilanyl-ethylcarboxyamino)-propionic acid methyl ester (7) has been prepared via alkylation of the histidine urea derivative (7S)-5,6,7,8-tetrahydro-7-(methoxycarbonyl)-5-oxoimidazo-[1,5-c]-pyrimidine (2) with Fmoc-protected 3-iodopropyl-amine, followed by ring opening with 2-trimethylsilylethanol. After Fmoc cleavage by HNEt2, the histidine amine derivative was coupled to biotin, to the pentapeptide leucine-enkephalin and to Vitamin B12-b-acid by amide formation, employing TBTU as the coupling reagent. In order to make the histidine accessible for labelling, the teoc protecting group was removed by either NBu4F (for the biotin conjugate) or by TFA (for the enkephalin and B12 conjugates). Reaction of a 10(-4) M solution of the bioconjugates with [99mTc(H2O)3(CO)3]+ at 50 degrees C for 30 min led to the formation of one single new peak in the HPLC radiochromatogram in each case, confirming quantitative labelling of the respective biomolecules. To assess the nature of the labelled compounds, the rhenium analogues with Re(CO)3 were also synthesised and similar retention times confirmed the identity with the 99mTc labelled conjugates.
