38221-21-5

Usage

Uses

Used in Pharmaceutical Research:
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a research compound for studying its potential role in the development and progression of neurological disorders such as Parkinson's disease and chronic alcoholism. 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE helps researchers understand the underlying mechanisms and pathways involved in these conditions.
Used in Drug Development:
In the pharmaceutical industry, 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a starting material or intermediate in the synthesis of potential therapeutic agents targeting neurological disorders. Its unique chemical structure allows for the development of novel drugs with potential neuroprotective or neurorestorative properties.
Used in Toxicology Studies:
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is also used in toxicology studies to investigate the effects of tetrahydroisoquinoline neurotoxins on the nervous system. This helps in understanding the potential risks and side effects associated with exposure to these compounds, contributing to the development of safer drugs and therapies for neurological conditions.

Upstream product

• 493-48-1 (S)-salsolidine 
• 493-48-1 (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) 
• 59709-57-8 6,7-Dihydroxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline monohydrobromide 
• 110691-51-5 (1S)-2<<(R)-1-phenylethyl>carbamoyl>salsolidine 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

Development of new HPLC chiral stationary phases based on native and derivatized cyclofructans

An unusual class of chiral selectors, cyclofructans, is introduced for the first time as bonded chiral stationary phases. Compared to native cyclofructans (CFs), which have rather limited capabilities as chiral selectors, aliphatic-and aromatic-functionalized CF6s possess unique and very different enantiomeric selectivities. Indeed, they are shown to separate a very broad range of racemic compounds. In particular, aliphatic-derivatized CF6s with a low substitution degree baseline separate all tested chiral primary amines. It appears that partial derivatization on the CF6 molecule disrupts the molecular internal hydrogen bonding, thereby making the core of the molecule more accessible. In contrast, highly aromaticfunctionalized CF6 stationary phases lose most of the enantioselective capabilities toward primary amines, however they gain broad selectivity for most other types of analytes. This class of stationary phases also demonstrates high "loadability" and therefore has great potential for preparative separations. The variations in enantiomeric selectivity often can be correlated with distinct structural features of the selector. The separations occur predominantly in the presence of organic solvents.