38226-31-2Relevant academic research and scientific papers
Highly selective probes of copper(II) complexes for sulfide detection and cytotoxicity assay
Chen, Yanmei,Shang, Xuefang,Zhao, Xing,Li, Jie,Yuan, Jianmei,Chen, Hongli,Zhang, Jinlian,Wang, Tianyun
, p. 308 - 321 (2018)
Two probes based on novel Copper(II) complexes were developed in order to obtain H2S molecular probes with higher selectivity. The molecular structures of the complexes were characterized by 1H NMR, HRMS, IR and elemental analysis. The interaction of the compounds with biologically important anions and amino acids was determined by UV-vis and Fluorescence titration experiments. Results indicated that the compounds showed the highest binding ability for HS? among studied anions (AcO?, H2PO4 ?, F?, Cl?, Br? and I?) and amino acids (GSH, HCys and Cys) accompanied by blue shift phenomenon in pure DMSO and aqueous solution. The possible mechanism of host–guest interaction may be that the Copper(II) ion of complex was captured by HS? and free ligand released which showed a remarkable changes in UV-vis absorption. In addition, cytotoxicity of the synthesized compounds was studied on MCF-7 cells. Results indicated that the synthesized compounds had low cytotoxicity over a concentration range of 0–150 μg?mL?1, which exhibited that the synthesized probes could be used to detect H2S in vivo. The probes based on novel copper(II) complexes were synthesized and obtained by the reaction of substituent salicylaldehyde with amine derivatives, and then reacted with Cu(CH3COO)2·H2O, respectively. Investigation on the interference from other species suggested that copper(II) complexes have high selectivity for HS? over other anions (AcO?, (Formula presented.), F?, Cl?, Br? and I?), followed by the release of the copper ion to give a remarkable increase in UV–VIS absorption in pure DMSO solution and aqueous solution.
