38253-98-4Relevant articles and documents
A new cobalt-salen catalyst for asymmetric cyclopropanation. Synthesis of the serotonin-norepinephrine repuptake inhibitor (+)-synosutine
White, James D.,Shaw, Subrata
supporting information, p. 3880 - 3883 (2014/08/18)
A new C2 symmetric cobalt(II)-salen catalyst based on cis-2,5-diaminobicyclo[2.2.2]octane as the chiral scaffold was prepared which, in the presence of potassium thioacetate as the promoter, catalyzed the formation of cyclopropanes from 1,1-dis
Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2- methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters
White, James D.,Juniku, Rajan,Huang, Kun,Yang, Jongtae,Wong, David T.
experimental part, p. 5872 - 5879 (2010/03/24)
Stereodefined trisubstituted cyclopropanes bearing naphthyloxy, thiophenyl, and (N-methylamino)-methyl groups were synthesized in enantiopure form employing asymmetric cyclopropanation of (E)- and (Z)-allylic alcohols as the key step. In vitro assays of the synthesized cyclopropanes revealed that the Ki of one of the enantiomers as a dual inhibitor of serotonin and norepinephrine transporters is in the low nanomolar range and is comparable to that of duloxetine. 2009 American Chemical Society.
