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38261-36-8

6-amino-4-(4-chlorophenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 38261-36-8 Structure

  • Basic information

    1. Product Name: 6-amino-4-(4-chlorophenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one
    2. Synonyms: 6-amino-4-(4-chlorophenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one
    3. CAS NO:38261-36-8
    4. Molecular Formula:
    5. Molecular Weight: 224.65
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 38261-36-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-amino-4-(4-chlorophenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-amino-4-(4-chlorophenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one(38261-36-8)
    11. EPA Substance Registry System: 6-amino-4-(4-chlorophenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one(38261-36-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 38261-36-8(Hazardous Substances Data)

38261-36-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 38261-36-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,2,6 and 1 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 38261-36:
(7*3)+(6*8)+(5*2)+(4*6)+(3*1)+(2*3)+(1*6)=118
118 % 10 = 8
So 38261-36-8 is a valid CAS Registry Number.

38261-36-8Upstream product

38261-36-8Downstream Products

38261-36-8Relevant articles and documents

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

Prati, Federica,De Simone, Angela,Armirotti, Andrea,Summa, Maria,Pizzirani, Daniela,Scarpelli, Rita,Bertozzi, Sine Mandrup,Perez, Daniel I.,Andrisano, Vincenza,Perez-Castillo, Ana,Monti, Barbara,Massenzio, Francesca,Polito, Letizia,Racchi, Marco,Sabatino, Piera,Bottegoni, Giovanni,Martinez, Ana,Cavalli, Andrea,Bolognesi, Maria L.

, p. 1665 - 1682 (2015)

One of the main obstacles toward the discovery of effective anti-Alzheimer drugs is the multifactorial nature of its etiopathology. Therefore, the use of multitarget-directed ligands has emerged as particularly suitable. Such ligands, able to modulate different neurodegenerative pathways, for example, amyloid and tau cascades, as well as cognitive and neurogenic functions, are fostered to come. In this respect, we report herein on the first class of BACE-1/GSK-3β dual inhibitors based on a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton, whose hit compound 1 showed interesting properties in a preliminary investigation. Notably, compound 2, endowed with well-balanced potencies against the two isolated enzymes (IC50 of 16 and 7 μM against BACE-1 and GSK-3β, respectively), displayed effective neuroprotective and neurogenic activities and no neurotoxicity in cell-based assays. It also showed good brain permeability in a pharmacokinetic assessment in mice. Overall, triazinone derivatives, thanks to the simultaneous modulation of multiple points of the diseased network, might emerge as suitable candidates to be tested in in vivo Alzheimer's disease models.

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