38270-24-5

Basic information

• Product Name: 3-(2-hydroxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one
• Synonyms: 3-(2-hydroxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one
• CAS NO: 38270-24-5
• Molecular Weight: 240.258
• Mol File: 38270-24-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(2-hydroxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one(38270-24-5)
• EPA Substance Registry System: 3-(2-hydroxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one(38270-24-5)

Safety Data

• Hazardous Substances Data: 38270-24-5(Hazardous Substances Data)

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 90-02-8 salicylaldehyde 
• 114590-73-7 1-(3-isopropoxyphenyl)ethanone 
• 22921-58-0 2-isopropoxybenzaldehyde 
• 5453-62-3 β-dimethylamino-m-hydroxypropiophenone hydrochloride 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 

Downstream Products

• 1362510-73-3 2-[2-(3-hydroxyphenyl)-6-phenylpyridin-4-yl]phenol 
• 80816-86-0 (3-Hydroxy-phenyl)-[2-(2-hydroxy-phenyl)-cyclopropyl]-methanone 
• 74973-32-3 (3-Methoxy-phenyl)-[2-(2-methoxy-phenyl)-cyclopropyl]-methanone 

Relevant articles and documents

Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison

Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups

Pro-angiogenic effects of chalcone derivatives in zebrafish embryos in vivo

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis.

Synthesis and pharmacological evaluation of some novel 2-pyrazolines bearing benzenesulfonamide as anti-inflammatory and blood glucose lowering agents

A series of novel pyrazolines (2a-l) bearing benzenesulfonamide moiety were synthesized by condensing appropriate chalcone (1a-l) with 4- hydrazinobenzenesulfonamide hydrochloride. Structure of all novel synthesized compounds was characterized on basis of