38286-64-5Relevant academic research and scientific papers
FUNCTIONALIZED PHOSPHONATES VIA MICHAEL ADDITION
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Paragraph 0254; 0379, (2018/03/10)
Provided herein are functionalized phosphonates and methods for making same via phosphite addition to an atom alpha to an electron withdrawing group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Phospha-Michael addition reaction of maleimides employing N-heterocyclic phosphine-thiourea as a phosphonylation reagent: synthesis of 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonate derivatives
Molleti, Nagaraju,Bjornberg, Chad,Kang, Jun Yong
, p. 10695 - 10704 (2016/11/30)
N-Heterocyclic phosphine (NHP)-thiourea as a novel phosphonylation reagent has been successfully applied for the phospha-Michael reaction of maleimides under catalyst and additive free reaction conditions. This methodology enables desymmetrization of a variety of maleimide derivatives to provide 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonates in up to 92% yield. Synthetic manipulation of this Michael adduct afforded an ethylphosphonate and a phosphino lactam. Furthermore, a scale-up experiment for its practical usage as a versatile precursor in organic synthesis was readily demonstrated.
Microwave-assisted phospha-Michael addition of dialkyl phosphites, a phenyl-H-phosphinate, and diphenylphosphine oxide to maleic derivatives
Balint, Erika,Takacs, Judit,Drahos, Laszlo,Keglevich, Gyoergy
experimental part, p. 235 - 240 (2012/07/28)
A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted phospha-Michael addition of dialkyl phosphites, ethyl phenyl-H-phosphinate, and diphenylphosphine oxide to N-phenyl and N-methyl maleimide, as well as to maleic acid anhydride.
