38309-89-6Relevant articles and documents
A bis-urea naphthalene macrocycle displaying two crystal structures with parallel ureas
Geer, Michael F.,Smith, Mark D.,Shimizu, Linda S.
, p. 3665 - 3669 (2011)
Herein we synthesized a bis-urea macrocycle from 2,7-dimethylnaphthalene that displays an unusual parallel urea conformation. The naphthalenes also adopt a bowl shape over the anticipated parallel planar orientation. Crystallization of the macrocycle from different solvent systems affords two solvated forms. 1·DMSO·(H2O)2 has an extended columnar structure where parallel macrocycles are linked by intervening hydrogen bonded water molecules. In 1·(MeOH)2 direct hydrogen-bonds link the macrocycles into chains, which hydrogen-bond with methanol molecules to form a layered structure.
COMPOUNDS USEFUL IN HIV THERAPY
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Page/Page column 242, (2020/06/19)
The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.
Distance between Metal Centres Affects Catalytic Efficiency of Dinuclear CoIII Complexes in the Hydrolysis of a Phosphate Diester
Bencze, Eva Szusanna,Zonta, Cristiano,Mancin, Fabrizio,Prins, Leonard J.,Scrimin, Paolo
, p. 5375 - 5381 (2018/10/26)
Dinuclear CoIII complex catalysed hydrolysis of bis-p-nitrophenylphosphate, a DNA model substrate, is reported. The catalysts were designed in such a way that the two CoIII ions cannot be contemporaneously involved in the complexation of the substrate or transition state. Experimental evidence of the involvement of such a remote metal centre in the catalysis of the hydrolysis of a phosphate diester is provided. This contribution amounts to a ca. 64-fold rate acceleration for the second-order rate constants of the best dinuclear complex over the mononuclear one, which is apparently due to general acid or H-bonding catalysis. Furthermore, there is significant distance dependence for this catalytic contribution and, in this case, it appears that the best distance (as estimated by DFT calculations) is ca. 7.7 ?. This may indicate that the presence of metal centres in close proximity, as required for mechanism proposals in which all metals are directly involved in transition-state coordination, is not the only option for rate acceleration in natural phosphate hydrolysis.
Bis-styrylnaphthalene and bis-styrylnaphthyridine derivatives with high binding affinity to ?2-amyloid fibrils
Lee, Yeo Ran,Kim, YoungSoo,Yoo, Kyung Ho
, p. 413 - 416 (2015/03/03)
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