383129-51-9

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 138772-65-3 tert-butyl ((2S)-1-(((2S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 13122-89-9 (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate 

Downstream Products

• 153864-35-8 tert-butyl (S)-1-oxo-3-phenyl-1-((S)-1-phenylbut-3-en-2-ylamino)propan-2-ylcarbamateas 
• 1414493-15-4 tert-butyl (2S,5S,6S)-2,5-dibenzyl-6-(iodomethyl)-3-oxopiperazine-1-carboxylate 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR MODULATING PROTEASE ACTIVITY

Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.

An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization

A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyc

Allyltrichlorostannane additions to chiral dipeptide aldehydes

The first examples of successful allylsilane additions to chiral dipeptide aldehydes are described. Treatment of allylsilanes with tin tetrachloride at room temperature affords allyltrichlorostannane intermediates that reacts with dipeptide aldehydes to give 1,2-syn-homoallylic alcohols, potential intermediates for the synthesis of hydroxyethylene dipeptide isosteres.