383137-35-7Relevant academic research and scientific papers
SnCl2 catalyzed direct synthesis of pyrroles under aqueous conditions
Tejeswararao,Srikanth
, p. 795 - 802 (2020)
Synthetic substituted pyrroles are related with interesting biological activities, yet they remain inadequately explored within drug discovery. Late years have seen a growing interest in synthetic approaches that can provide access to structurally novel pyrroles so that the biological usefulness of this compound class can be more fully investigated. Herein, an efficient and versatile practical protocol for the pyrroles using stannous(II) chloride dihydrate as catalyst is described under aqueous conditions at 55 oC in high yields. Also, this method is applicable for the preparation of diversity and oriented pyrrole derivatives.
A convenient one-pot access to N-substituted pyrroles from nitro benzenes under neat aqueous conditions
Bose, D. Subhas,Srikanth, Bingi
, p. 1112 - 1116 (2017/04/28)
A practical and straightforward one-step procedure for the synthesis of N-functionalized pyrroles via reductive cyclization is described. The simple one-pot reaction is carried out by treating various substituted nitro benzenes with readily available building blocks 2,5-dimethoxytetrahydrofuran or γ-diketone in the presence of SnCl2 under aqueous conditions at 55°C.
Iron-catalyzed inexpensive and practical synthesis of N-substituted pyrroles in water
Azizi, Najmedin,Khajeh-Amiri, Alireza,Ghafuri, Hossein,Bolourtchian, Mohammad,Saidi, Mohammad Reza
experimental part, p. 2245 - 2248 (2009/12/03)
An operationally simple, practical, and economical protocol for iron(III) chloride catalyzed Paal-Knorr pyrrole synthesis in water in good to excellent yields has been developed. Several N-substituted pyrroles are readily prepared from the reaction of 2,5-dimethoxytetrahydrofuran and aryl/alkyl, sulfonyl and acyl amines under very mild reaction conditions. Georg Thieme Verlag Stuttgart.
