38324-83-3

Basic information

• Product Name: 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID
• Synonyms: 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID;5-Pyrimidinecarboxylic acid, 1,2-dihydro-2-oxo- (9CI);2-Hydroxypyrimidine-5-carboxylic acid 98%;5-Carboxypyrimidin-2-ol;2-oxo-1,2-dihydropyriMidine-5-carboxylic acid;5-PyriMidinecarboxylic acid, 1,2-dihydro-2-oxo-;5-PyriMidinecarboxylic acid, 2-hydroxy-;2-Hydroxy-1,3-diazine-5-carboxylic acid, 5-Carboxy-2-hydroxypyrimidine
• CAS NO: 38324-83-3
• Molecular Formula: C₅H₄N₂O₃
• Molecular Weight: 140.1
• EINECS: 1312995-182-4
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 38324-83-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: >200 °C
• Appearance: /
• Density: 1.636 g/cm³
• Refractive Index: 1.662
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.17±0.20(Predicted)
• CAS DataBase Reference: 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID(38324-83-3)
• EPA Substance Registry System: 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID(38324-83-3)

Safety Data

• Hazardous Substances Data: 38324-83-3(Hazardous Substances Data)

Usage

General Description

2-Hydroxypyrimidine-5-carboxylic acid is a chemical compound with the molecular formula C5H4N2O3. It is a derivative of pyrimidine and belongs to the class of carboxylic acids. 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and potential biological activity. It has been studied for its potential applications in the medical field, specifically in the development of novel drugs for various therapeutic indications. Additionally, 2-Hydroxypyrimidine-5-carboxylic acid has also been investigated for its potential use as a corrosion inhibitor and as a building block for the development of functional materials.

InChI:InChI=1/C5H4N2O3/c8-4(9)3-1-6-5(10)7-2-3/h1-2H,(H,8,9)(H,6,7,10)

Upstream product

• 37131-88-7 2-Ethylmercapto-pyrimidin-5-carbonsaeure 
• 151323-66-9 ethyl 2-(ethylthio)pyrimidine-5-carboxylate 
• 73781-88-1 ethyl 2-(methylthio)pyrimidine-5-carboxylate 

Downstream Products

• 110099-99-5 2-CHLOROPYRIMIDINE-5-CARBONYLCHLORIDE 
• 110100-02-2 (2-chloropyrimidin-5-yl)(phenyl)methanone 
• 110100-07-7 1-benzyl-5-pentanoyl-2(1H)-pyrimidinone 
• 1072930-25-6 [5-(7-chloro-1-propyl-1H-benzoimidazol-2-yl)-pyrimidin-2-yl]-(4-methoxy-phenyl)-amine 
• 1383006-34-5 (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate 

Relevant articles and documents

Method for synthesizing 2-chloro/hydroxypyrimidine-5-carboxylic acid

The invention discloses a method for synthesizing 2-chloro/hydroxypyrimidine-5-carboxylic acid, and belongs to the field of synthesis of pharmaceutical intermediates. The invention comprises the following steps: reacting 2-chloro-5-bromopyrimidine with Boc2O under action of an active metallic reagent; then, adding an aqueous acid solution or an aqueous alkali solution to reflux at room temperature; and treating to obtain 2-chloropyrimidine-5-carboxylic acid and 2-hydroxypyrimidine-5-carboxylic acid, respectively. The method avoids a problem of low yield during scale-up by a method of feeding CO2, has good batch-to-batch operation reproducibility, and provides a new way for production scale-up.

Organomanganese(II) Reagents in the Synthesis of 5-Pyrimidinyl Ketones

Substituted alkyl 5-pyrimidinyl ketones were formed from acid chlorides of pyrimidine-5-carboxylic acids and alkylmanganese(II) iodides.The corresponding alcohols were also formed in the case of sterically less requiring organomanganese reagents and the a