38339-31-0Relevant academic research and scientific papers
Merging Br?nsted Acid and Hydrogen-Bonding Catalysis: Metal-Free Dearomatization of Phenols via ipso-Friedel-Crafts Alkylation to Produce Functionalized Spirolactams
Harada, Shingo,Kwok, Irene Mei-Yi,Nakayama, Hiroki,Kanda, Ayaka,Nemoto, Tetsuhiro
, p. 801 - 807 (2018)
Intramolecular dearomative cyclization of phenols with α-diazoamide units for synthesizing functionalized spirolactams was developed by merging Br?nsted acid and hydrogen-bonding catalysis as an advantageous alternative to transition metal catalysis. This metal carbenoid-free strategy enables high chemoselectivity by suppressing potentially competing C?H insertion reactions and a Büchner reaction. Preliminary mechanistic studies were performed to elucidate the positive effect of the combined use of the catalysts, and extension to an asymmetric reaction was achieved. (Figure presented.).
Substituted (10H-phenothiazin-10-L)-propyl-1-piperazines
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, (2008/06/13)
Substituted (10H-phenothiazin-10-yl)propyl-1-piperazines of the formula STR1 wherein R1, R2, R3, A, X, m, n and s are as hereinafter set forth, are described. The compounds of formula I, which contain a piperazine moiety combined by an ether linkage to different phenolic moieties, are useful as orally active long lasting antipsychotic agents.
