3835-41-4

Usage

Uses

Due to the potential health risks associated with 6-Methylimidazo[2,1-b]thiazole, its primary use is not as a direct application in industries but rather as a compound to be mitigated or avoided. However, efforts to reduce its formation in cooked foods can be considered as its indirect application in the food industry.
Used in Food Industry:
6-Methylimidazo[2,1-b]thiazole is targeted for reduction in the formation of potentially harmful compounds during the cooking process. It is used as a reference point for implementing changes in cooking methods or adding specific ingredients that can inhibit its formation, thereby enhancing food safety and reducing the risk of cancer associated with its consumption.

Upstream product

• 57626-37-6 ethyl 6-methylimidazo<2.1-b>thiazole-5-carboxylate 

Downstream Products

• 75001-31-9 6-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde 
• 83253-34-3 6-methylimidazo[2,1-b][1,3]thiazole-5-carbonitrile 
• 438017-82-4 C₂₀H₃₀N₅PS 
• 83253-29-6 6-Methyl-imidazo[2,1-b]thiazole-5-carbaldehyde oxime 

Relevant academic research and scientific papers

Reaction of 2-Aminothiazoles with Reagents containing a C-Halogen and a C=O Electrophilic Centre

Seven reagents of different types having in common a C-Hal and a C=O electrophilic centre have been used in a study of their reactions with 2-aminothiazoles.Three reagents, CHBrAc2 and ROCHBrCO2Et (R = Me, Ph), gave imidazothiazoles, thus providing useful routes to the 5-acetyl and 5-ethoxycarbonyl derivatives.Unexpectedly, the solvent (acetone) was involved in the reaction of the fourth reagent, CHBr(CO2Et)2, with 2-aminothiazole which led to 5,5-di(ethoxycarbonyl)-6,6-dimethyl-5,6-dihydroimidazothiazole (yield 81percent).With the last three reagents (AcCHBrNO2, BzCHBrCN and ICH2CO2C6H4NO2-p) the outcome was simpler, viz., the formation of 2-amidothiazoles.It is proposed that electrophilic attack by the endo-N of the 2-aminothiazole is the first step in all cases.This occurs at the C-Hal centre of the first four reagents and is followed by cyclisation to the exo-N.In the last three electrophiles the presence of the groups well suited to leaving as stabilised anions favours addition to the C=O group; the intermediates so formed subsequently isomerise to the more stable exo-N substituted products.

Substituted imidazo[2,1-b]thiazoles from 2-aminothiazoles and α-bromo ketones: Efficient preparation and proof of structure

The salts formed from α-aminothiazoles and α-bromo ketones (RCOCH2Br) have been basified, and the products converted into amides. Examination of the amides established that they are 2-acylimino-2,3- dihydrothiazoles rather than 2-acylaminothiaz