38351-11-0

Upstream product

• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 108-67-8 1,3,5-trimethyl-benzene 

Downstream Products

• 5344-18-3 2-methylpropyl 2,4,6-trimethylphenyl ketone 
• 135594-52-4 3,3-Dimethyl-1-(2,4,6-trimethyl-phenyl)-hex-5-en-1-one 
• 135594-53-5 3,3,5-Trimethyl-1-(2,4,6-trimethyl-phenyl)-hex-5-en-1-one 
• 135594-54-6 3,3,4-Trimethyl-1-(2,4,6-trimethyl-phenyl)-hex-5-en-1-one 
• 51060-32-3 Acetic acid (E)-3-methyl-3-phenyl-1-(2,4,6-trimethyl-phenyl)-but-1-enyl ester 
• 51060-31-2 Acetic acid (Z)-3-methyl-3-phenyl-1-(2,4,6-trimethyl-phenyl)-but-1-enyl ester 
• 51060-34-5 Acetic acid (E)-3,3-dimethyl-1-(2,4,6-trimethyl-phenyl)-but-1-enyl ester 
• 51060-33-4 Acetic acid (Z)-3,3-dimethyl-1-(2,4,6-trimethyl-phenyl)-but-1-enyl ester 

Relevant academic research and scientific papers

Facile synthesis of dihydrochalcones via the AlCl3-promoted tandem Friedel-Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides

Tandem Friedel-Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides were investigated under the catalysis of Lewis acids. The cascade reaction affords dihydrochalcones in good yields accompanying 1-indanone derivatives in some cases, in the presence of anhydrous aluminum chloride. The scope, limitation, and mechanism of the tandem reaction were also explored. The intermolecular Friedel-Crafts alkylation for the formation of dihydrochalcones is more favorable than the intramolecular one for the generation of 1-indanones in the tandem reaction due to a stable six-membered ring transition state. The sequent process was further studied by the DFT computations at the M06-2X/6-31G(d) level, which are in great agreement with the experimental observation and support the proposed mechanism. The current method provides a convenient and economic method to synthesis of dihydrochalcones.

Addition conjuguee d'organometalliques sur des mesitylcetones α-ethyleniques

Reactions of α-ethylenic mesitylketones with a series of organometallic compounds including allylic orgnometallics and organolithium compounds proceed via exclusive conjugated additions as a result of the steric congestion of the carbonyl of these ketones