38370-36-4Relevant academic research and scientific papers
A novel method for the t-butylation of aromatic amines
Genin, Michael J.,Biles, Carolyn,Romero, Donna L.
, p. 4301 - 4304 (2007/10/02)
A new method for the synthesis of t-butylamines from amines in two steps via α-aminonitriles, and its application to various arylamines is discussed.
Acid-Catalyzed Reactions of N-Arylhydroxylamines and Related Compounds with Benzene. Iminium-Benzenium Ions
Shudo, Koichi,Ohta, Toshiharu,Okamoto, Toshihiko
, p. 645 - 653 (2007/10/02)
N-Arylhydroxylamines react with benzene in the presence of trifluoroacetic acid (TFA) at room temperature to give diphenylamines.When TFA was replaced by a strong acid, trifluoromethanesulfonic acid (TFSA), the major products were aminobiphenyls.The nature of the reaction was explored by reactions of 4-substituted phenylhydroxylamines and dialkylaniline N-oxides with benzene.Thus, it was demonstrated that the reactive intermediates are onium-benzenium dications which are trapped by benzene to give aminobiphenyls by a mechanism similar to the Friedel-Krafts alkylation.Further evidence for the proposed reaction mechanism was the observation that nitrosobenzene and azoxybenzene reacted with benzene to give analogous products in the presence of the stronger acid.
