38373-94-3

Upstream product

• 941-98-0 1'-naphthacetophenone 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 126584-15-4 2-Naphth-(1)-yl-4-(p-bromophenyl)-3,4-dihydrotetrazolo<4,5-a>pyrimidine 
• 142746-06-3 5-(4-Bromo-phenyl)-3-naphthalen-1-yl-4,5-dihydro-isoxazole 
• 126584-18-7 2-Naphth-(1)-yl-4-(p-bromophenyl)-3,4-dihydro-5-oxo-6-phenylpyrazolo<3,4-b>pyridine 
• 126584-17-6 2-Naphth-(1)-yl-4-(p-bromophenyl)-benzimidazolo<1,2-a>pyrimidine 

Relevant academic research and scientific papers

A general, mild and efficient palladium-catalyzed 2,2,2-trifluoroethoxylation of activated aryl bromides and bromo-chalcones: Bromo-chalcones a new coupling partner in cross-coupling reaction

An efficient protocol for Pd-catalyzed 2,2,2-trifluoroethoxylation of activated aryl bromides and bromo-chalcones has been developed. We unveil a fascinating insight into the Pd-catalyzed C-O cross-coupling reaction. Pd/tBuXPhos (L1) ligand system facilitates the C-O cross-coupling reaction between 2,2,2-trifluoroethanol and activated aryl bromides at both higher (115 °C) and lower temperatures (40 °C). Unprecedentedly, this catalyst system facilitates the C-O cross-coupling reaction in short span of reaction times, generally 5-25 min (at 115 °C). The structurally simple analogue of tBuXPhos ligand so called JohnPhos (L2) ligand is also facilitated the C-O bond formation with activated aryl bromides and bromo-chalcones. Interestingly, under the optimal conditions (L1), methanol is also coupled rapidly with activated aryl bromides. These catalyst systems (L1 and L2) fail to couple electron rich aryl bromides with 2,2,2-trifluoroethanol, thus these catalyst systems allow the reductive elimination through an electronic pathway of reductive elimination. The unusual reactivity of 2,2,2-trifluoroethanol in Pd-catalyzed C-O cross-coupling reaction makes that the chemistry of fluorinated molecules is unique than that of non-fluorinated analogues. The bromo-chalcones can be used as a new coupling partner in the cross-coupling reaction.

ROR GAMMA MODULATORS

There are described ROR? modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising th

Synthesis of new 3-(4-fluoronaphthyl)-5-(aryl)-2-isoxazolines and their antimicrobial and spermicidal activity

Microwave assisted synthesis of 3-(4-fluoronaphthyl)-5-(aryl)-2- isoxazolines (3) from corresponding chalcones (2) and hydroxylamine hydrochloride has been accomplished. Structures of synthesized compounds have been confirmed on the basis of spectral studies (IR, 1H NMR) and analytical data. Representative compounds have been screened for their spermicidal activity in HF cattle and were also evaluated for their antibacterial activity against Staphylococcus aureus, E coli, Pseudomonas and antifungal activity against Candida albicans, Asperigillus niger, Fusarium oxysporum.