38384-44-0Relevant academic research and scientific papers
First pinacol coupling in emulsified water: Key role of surfactant and impact of alternative activation technologies
Billamboz, Muriel,Len, Christophe
, p. 1664 - 1675 (2015)
For the first time, the influence of surfactants on the radical pinacol coupling reaction is investigated. The rate and selectivity of this reductive C-C coupling are compared under three different activation technologies: thermal activation, microwave irradiation, and sonication. The use of IgepalCO520, a neutral surfactant, led to the successful conversion of aromatic or α,β-unsaturated aliphatic carbonyl compounds in moderate to excellent yield (55-90 %). An insight on the potential mechanism involved in the reaction is also proposed, based on microscopic observations and particle size measurement.
