38385-95-4

Basic information

• Product Name: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
• Synonyms: CHEMBRDG-BB 4003376;AKOS BBS-00005832;2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE;2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE;2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE;2-(4-PIPERIDYL)-1H-1,3-BENZIMIDAZOLE;OTAVA-BB BB7020410139;TIMTEC-BB SBB002504
• CAS NO: 38385-95-4
• Molecular Formula: C₁₂H₁₅N₃
• Molecular Weight: 201.27
• EINECS: 1312995-182-4
• Mol File: 38385-95-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 230 °C (decomp)(Solv: water (7732-18-5))
• Boiling Point: 441.3 °C at 760 mmHg
• Flash Point: 220.7 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 5.48E-08mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 11.83±0.10(Predicted)
• CAS DataBase Reference: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE(38385-95-4)
• EPA Substance Registry System: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE(38385-95-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 38385-95-4(Hazardous Substances Data)

Usage

General Description

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE is a chemical compound with a molecular formula of C15H18N4. It is a heterocyclic compound containing a benzimidazole ring and a piperidine ring. This chemical has been studied for its potential pharmaceutical properties, including as an anti-cancer agent, and as a potential treatment for various medical conditions such as psychiatric disorders and infectious diseases. Its unique structure and potential therapeutic effects make it an interesting compound for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C12H15N3/c1-2-4-11-10(3-1)14-12(15-11)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,15)

Upstream product

• 498-94-2 isonipecotic acid 
• 95-54-5 1,2-diamino-benzene 
• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 

Downstream Products

• 400797-32-2 1-[1-{3-[4-(1H-Benzoimidazol-2-yl)-piperidin-1-yl]-2-hydroxy-propyl}-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone 
• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 1159096-73-7 (4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)methanone 
• 1159096-67-9 [4-(1H-benzimidazol-2-yl)piperidin-1-yl][4-(pyridin-2-yl)phenyl]methanone 
• 1159096-70-4 C₂₄H₂₈N₄O 
• 605627-96-1 [4-(1H-benzimidazol-2-yl)piperidin-1-yl](4-bromophenyl)methanone 
• 1159096-69-1 C₂₅H₂₉N₃O 
• 1159096-75-9 C₂₅H₂₉N₃O 
• 1159096-72-6 [4-(1H-benzimidazol-2-yl)piperidin-1-yl](4'-methoxybiphenyl-4-yl)methanone 
• 1159096-79-3 C₂₅H₂₅N₅O₂ 
• 1159096-81-7 2-[1-(biphenyl-4-ylsulfonyl)piperidin-4-yl]-1H-benzimidazole 
• 1159096-77-1 [4-(1H-benzimidazol-2-yl)piperidin-1-yl](2-phenylpyrimidin-5-yl)methanone 
• 1159096-65-7 [4-(1H-benzimidazol-2-yl)piperidin-1-yl][4-(pyridin-4-yl)phenyl]methanone 
• 1159096-80-6 3-{[4-(1H-benzimidazol-2-yl)piperidin-1-yl]carbonyl}-6-phenylpyridin-2(1H)-one 

Relevant articles and documents

Substituted benzimidazoles as modulators of Ras signaling

Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents

A novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 5 with good anti-inflammatory activity was identified from our in-house library. Based on hit compound 5, two series of 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 6a-g and 7a-h were designed and synthesized as novel anti-inflammatory agents. Most of synthesized compounds exhibited good inhibitory activity on NO and TNF-α production in LPS-stimulated RAW 264.7 macrophages, in which the compound 6e showed most potent inhibitory activity on NO (IC50 = 0.86 μm) and TNF-α (IC50 = 1.87 μm) production. Further evaluation revealed that compound 6e displayed more potent in vivo anti-inflammatory activity than ibuprofen did on xylene-induced ear oedema in mice. Additionally, Western blot analysis revealed that compound 6e could restore phosphorylation level of IκBα and protein expression of p65 NF-κB in LPS-stimulated RAW 264.7 macrophages.

DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS

Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.