383910-59-6

Basic information

• Product Name: C₇₁H₁₁₉O₁₅N₅Si₂CH₂O
• Synonyms: C₇₁H₁₁₉O₁₅N₅Si₂CH₂O
• CAS NO: 383910-59-6
• Molecular Weight: 1368.95
• Mol File: 383910-59-6.mol

Chemical Properties

• CAS DataBase Reference: C₇₁H₁₁₉O₁₅N₅Si₂CH₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₇₁H₁₁₉O₁₅N₅Si₂CH₂O(383910-59-6)
• EPA Substance Registry System: C₇₁H₁₁₉O₁₅N₅Si₂CH₂O(383910-59-6)

Safety Data

• Hazardous Substances Data: 383910-59-6(Hazardous Substances Data)

Upstream product

• 383910-57-4 Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxy-isoquinoline)-O-Boc-threonine-OSEM 
• 383910-55-2 N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM 
• 383910-56-3 (S)-7-Methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester 
• 383910-52-9 methyl N-Cbz-L-1,2,3,4-tetrahydro-7-methoxy-6,8-di-iodoisoquinoline-3-carboxylate 
• 383910-53-0 methyl N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylate 
• 383910-54-1 N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic acid 
• 126587-71-1 Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester 
• 126587-57-3 (3S,4R,5S)-4-Amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (1S,2S,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-2-methoxymethoxy-3-methyl-butyl ester 
• 383910-58-5 Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine 

Downstream Products

• 383910-61-0 C₆₆H₁₀₅N₅O₁₇Si 
• 383910-60-9 C₆₆H₁₀₇N₅O₁₆Si 

Relevant articles and documents

Total syntheses of conformationally constrained didemnin B analogues. Replacements of N2O-dimethyltyrosine with L-1,2,3,4-tetrahydroisoquinoline and L-1,2,3,4-tetrahydro-7-methoxyisoquinoline

The design and synthesis of two conformationally constrained analogues of didemnin B are described. The [N,O-Me2Tyr5]residue of didemnin B was replaced with L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) and L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic acid (MeO-Tic), which mimic the N,O-dimethylated tyrosine while constraining the conformation of the molecule. Preliminary results indicate that the conformation of the [N,O-Me2Tyr5]residue closely matches the conformation imposed by the Tic replacement.