384-16-7

Basic information

• Product Name: 2-BROMO-3-CHLOROBENZOTRIFLUORIDE
• Synonyms: 2-BROMO-3-CHLOROBENZOTRIFLUORIDE;2-BroMo-1-chloro-3-(trifluoroMethyl)benzene;2-Bromo-3-chloro-alpha,alpha,alpha-trifluorotoluene
• CAS NO: 384-16-7
• Molecular Formula: C₇H₃BrClF₃
• Molecular Weight: 259.45
• Mol File: 384-16-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 198.4°Cat760mmHg
• Flash Point: 73.8°C
• Appearance: /Solid
• Density: 1.717g/cm³
• Vapor Pressure: 0.507mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-3-CHLOROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-CHLOROBENZOTRIFLUORIDE(384-16-7)
• EPA Substance Registry System: 2-BROMO-3-CHLOROBENZOTRIFLUORIDE(384-16-7)

Safety Data

• Hazardous Substances Data: 384-16-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-chlorobenzotrifluoride is a chemical compound with the molecular formula C7H4BrClF3. It is a clear, colorless liquid that is used as a building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. 2-Bromo-3-chlorobenzotrifluoride is primarily used as an intermediate in the synthesis of various compounds, including medicines and agrochemicals. It is also employed as a solvent in organic synthesis and as a valuable reagent in the preparation of fluorine-containing compounds. Additionally, it is used as a raw material in the manufacturing of dyes and other organic chemicals. Due to its properties and applications, 2-Bromo-3-chlorobenzotrifluoride is an important compound in the chemical industry.

InChI:InChI=1/C7H3BrClF3/c8-6-4(7(10,11)12)2-1-3-5(6)9/h1-3H

Upstream product

• 914225-58-4 4-bromo-3-chloro-5-(trifluoromethyl)aniline 
• 914225-53-9 2-bromo-3-trifluoromethyl-5-nitro-chlorobenzene 
• 367-67-9 2-bromo-5-nitro-benzotrifluoride 

Downstream Products

• 865352-01-8 2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride 
• 1289519-62-5 2-deutero-1-chloro-3-(trifluoromethyl)benzene 

Relevant articles and documents

Synthesis method of 2-(2, 2-difluoroethyoxyl)-6-trifluoromethyl benzenesulfonyl chloride

The invention discloses a synthesis method of 2-(2, 2-difluoroethyoxyl)-6-trifluoromethyl benzenesulfonyl chloride. The preparation method comprises the following steps: dissolving 2-trifluoromethyl-4-nitro-bromobenzene in sulfuric acid, adding a halogenating reagent, and reacting at 50-100 DEG C for 1-8 hours; dissolving the obtained 2-bromo-3-trifluoromethyl-5-nitro-benzene halide in a solvent, and performing reduction in a reduction system; carrying out diazotization on the obtained 3-halo-4-bromo-5-trifluoromethyl-aniline, and then carrying out decomposition on the obtained 3-halo-4-bromo-5-trifluoromethyl-aniline; carrying out Grignard reaction on the obtained 2-bromo-3-trifluoromethyl-benzene halide, and then reacting with dialkyl disulfide; carrying out etherification reaction on the obtained 2-alkylthio-3-trifluorotoluene-benzene halide and 2, 2-difluoroethanol in an organic solvent under the action of an alkali; and reacting the obtained 2-(2, 2-difluoroethoxy)-6-trifluoromethyl-phenylalkyl sulfide with chlorine gas at 10-60 DEG C for 1-5 hours. The method is short in route, mild in condition, high in yield and suitable for industrial production.