3840-18-4

Usage

Application

2-(2-Methylphenoxy)aniline is a useful research chemical.

InChI:InChI=1/C13H13NO/c1-10-6-2-4-8-12(10)15-13-9-5-3-7-11(13)14/h2-9H,14H2,1H3

Upstream product

• 54106-40-0 1-methyl-2-(2-nitrophenoxy)benzene 
• 95-48-7 ortho-cresol 
• 88-73-3 2-Chloronitrobenzene 
• 3235-09-4 potassium o-cresolate 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 206262-24-0 2-o-tolyloxy-benzenesulfonyl chloride 
• 884512-16-7 1-iodo-2-(2-tolyloxy)benzene 
• 35486-82-9 4-amino-9H-xanthen-9-one 
• 5396-28-1 4-methylxanthen-9-one 
• 1071865-97-8 (3R)-tert-butyl 3-(1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxypentyl)piperidine-1-carboxylate 
• 794518-74-4 2-(2-acetylamino-phenoxy)-benzoic acid 
• 76840-92-1 Imidazolidin-2-ylidene-(2-o-tolyloxy-phenyl)-amine 
• 76838-99-8 (2-o-Tolyloxy-phenyl)-thiourea 

Relevant academic research and scientific papers

Design, synthesis and antifungal activity of novel furancarboxamide derivatives

Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.

A Fast Way to Fluorescence: A Fourfold Domino Reaction to Condensed Polycyclic Compounds

A fast and efficient palladium-catalyzed fourfold domino Sonogashira/double-carbopalladation/C H-activation reaction that converts simple aromatic systems into complex polycyclic hydrocarbons has been developed. A number of substituted products has thus been prepared in yields up to 89 %. The structural assignment has been confirmed by using single-crystal X-ray crystallography. The products show intriguing fluorescence activity and thus might serve as chemical sensors or fluorescent imaging dyes.

Synthesis and enantioselective hydrogenation of seven-membered cyclic imines: Substituted dibenzo[b,f][1,4]oxazepines

Highly enantioselective hydrogenation of seven-membered cyclic imines, substituted dibenzo[b,f][1,4]oxazepines, was achieved, with up to 94% ee, by using the [Ir(COD)Cl]2/(S)-Xyl-C3*-TunePhos complex as the catalyst in the presence of morpholine-HCl.

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.