38405-69-5

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 876-92-6 2-phenyl-2,4-dihydro-pyrazol-3-one 

Downstream Products

• 38405-74-2 1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 
• 54367-64-5 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 1334735-76-0 6-butyl-1-phenyl-1H-pyrazolo[4,3-c]pyridine 
• 1334735-75-9 1-phenyl-6-(3-thienyl)-1H-pyrazolo[4,3-c]pyridine 
• 1334735-72-6 1,6-diphenyl-1H-pyrazolo[4,3-c]pyridine 
• 1334735-54-4 5-hex-1-ynyl-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 1334735-50-0 1-phenyl-5-(phenylethynyl)-1H-pyrazole-4-carbaldehyde 
• 1334735-51-1 1-phenyl-5-(3-thienylethynyl)-1H-pyrazole-4-carbaldehyde 

Relevant academic research and scientific papers

Sonogashira-type reactions with 5-chloro-1-phenyl-1H-pyrazole-4- carbaldehydes: A straightforward approach to pyrazolo[4,3-c]pyridines

The easily obtainable 5-chloro-1-phenyl-1H-pyrazole-4-carbaldehydes 2 were used as precursors in Sonogashira-type cross-coupling reactions with various alkynes to provide the corresponding 5-alkynyl-1H-pyrazole-4-carbaldehydes 3. Treatment of these with t

Heterocyclic analogues of xanthone and xanthione. 1H-pyrano[2,3-c:6,5-c] dipyrazol-4(7H)-ones and thiones: Synthesis and NMR data

The synthesis of the title compounds is described. Reaction of 1-substituted 2-pyrazolin-5-ones with 5-chloro-1-phenyl-1H-pyrazole-4-carbonyl chloride or 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl chloride, respectively, using calcium hydroxide in refluxing 1,4-dioxane gave the corresponding 4-heteroaroylpyrazol-5-ols, which were cyclized into 1H-pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones by treatment with K 2CO3/DMF. The latter were converted into the corresponding thiones upon reaction with Lawesson's reagent. Detailed NMR spectroscopic investigations (1H, 13C, 15N) of the ring systems and their precursors are presented.