38409-70-0

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-(acetylamino)- (9CI)
• Synonyms: Cyclopropanecarboxylic acid, 1-(acetylamino)- (9CI);1-Acetylamino-1-cyclopropanecarboxylic acid;1-acetamidocyclopropanecarboxylic acid;1-acetylamino-cyclopropanecarboxylic acid
• CAS NO: 38409-70-0
• Molecular Formula: C₆H₉NO₃
• Molecular Weight: 143.14056
• Product Categories: AMINOACID
• Mol File: 38409-70-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-(acetylamino)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-(acetylamino)- (9CI)(38409-70-0)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-(acetylamino)- (9CI)(38409-70-0)

Safety Data

• Hazardous Substances Data: 38409-70-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Cyclopropanecarboxylic acid, 1-(acetylamino)(9CI) is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique cyclopropane ring and acetylamino group provide specific reactivity and structural features that are valuable in the synthesis of pharmaceuticals and agrochemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Cyclopropanecarboxylic acid, 1-(acetylamino)(9CI) is used as a building block for the development of new drugs. Its structural components can be incorporated into drug candidates to impart desired pharmacological properties, such as improved binding affinity, selectivity, and bioavailability.
Used in Pharmaceutical Industry:
Cyclopropanecarboxylic acid, 1-(acetylamino)(9CI) is utilized in the pharmaceutical industry as a precursor for the production of various pharmaceuticals. Its presence in drug molecules can contribute to their efficacy and safety, making it an important component in the development of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, Cyclopropanecarboxylic acid, 1-(acetylamino)(9CI) may be used as an intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure can be leveraged to create compounds with specific pesticidal or herbicidal properties, contributing to the development of more effective and targeted agrochemical products.

Upstream product

• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 108-24-7 acetic anhydride 
• 72784-49-7 ethyl 1-acetamidocyclopropanecarboxylate 

Relevant articles and documents

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

The von Hippel-Lindau tumor suppressor protein is the substrate binding subunit of the VHL E3 ubiquitin ligase, which targets hydroxylated α subunit of hypoxia inducible factors (HIFs) for ubiquitination and subsequent proteasomal degradation. VHL is a potential target for treating anemia and ischemic diseases, motivating the development of inhibitors of the VHL:HIF-α protein-protein interaction. Additionally, bifunctional proteolysis targeting chimeras (PROTACs) containing a VHL ligand can hijack the E3 ligase activity to induce degradation of target proteins. We report the structure-guided design and group-based optimization of a series of VHL inhibitors with low nanomolar potencies and improved cellular permeability. Structure-activity relationships led to the discovery of potent inhibitors 10 and chemical probe VH298, with dissociation constants 100 nM, which induced marked HIF-1α intracellular stabilization. Our study provides new chemical tools to probe the VHL-HIF pathways and new VHL ligands for next-generation PROTACs.

Regulating plant growth with novel 1-amino-cyclopropanecarboxylic acid metal complexes

1-Amino-cyclopropanecarboxylic acid metal complexes of the formula STR1 in which R is a hydrogen atom or a radical of the formula --CO--R1, R1 is a hydrogen atom or an alkyl or phenyl radical, and M is a transition metal atom which can assume the coordination number 4 which possess plant growth regulating activity.