3842-68-0

Usage

Molecular structure

Aromatic diamine derived from benzene

Appearance

Colorless to pale yellow solid or liquid

Solubility

Soluble in water, ethanol, and ether

Uses

a. Hair dyes and hair coloring products
b. Rubber industry as an antiozonant and accelerator
c. Dye manufacturing for textiles, leather, and paper

Properties

a. Produces vibrant and long-lasting colors
b. Acts as a reducing agent

Safety concerns

a. Potential for allergic reactions and skin sensitization
b. Suspected human carcinogen (based on animal studies)

Regulations and restrictions

Subject to regulations and restrictions in some countries due to safety concerns

Alternatives

Some hair care products use alternative ingredients to reduce the risk of allergic reactions and health concerns associated with p-Phenylenediamine.

Upstream product

• 5963-51-9 1,2-bis(3,4-dimethoxyphenyl)ethane 
• 18513-98-9 3,4,3',4'-Tetramethoxystilben 
• 554-34-7 1,2-bis(3,4-dimethoxyphenyl)ethane-1,2-dione 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 80784-19-6 5-[2-(1,3-benzodioxol-5-yl)ethyl]-1,3-benzodioxole 
• 5385-62-6 3,3’,4,4’-tetramethoxystilbene 
• 5463-22-9 vanillil 
• 6309-15-5 3,3',4,4'-tetrahydroxybenzil 

Downstream Products

• 102752-21-6 bibenzyltetrayl-(3.4.3'.4')-tetraacetate 
• 1245723-97-0 p-tolylboronic acid bis(catechol)ethane diester 
• 1257414-28-0 2,2'-dibromo-4,4',5,5'-tetrahydroxybibenzyl 
• 1257414-29-1 2,2',3-tribromo-4,4',5,5'-tetrahydroxybibenzyl 

Relevant academic research and scientific papers

Self-assembly of a cavitand-based capsule by dynamic boronic ester formation

Be my guest: Two molecules of a cavitand tetraboronic acid and four molecules of a bis(catechol) linker quantitatively assemble into a capsule (see picture for two views), with highly selective guest-recognition, by dynamic boronic ester formation. The on

Total synthesis of the marine metabolite (±)-Polysiphenol via highly regioselective intramolecular oxidative coupling

(±)-Polysiphenol (1), an atropisomerically stable 4,5-dibrominated 9,10-dihydrophenanthrene from Polysiphonia ferulacea, was prepared by a biomimetically inspired highly regioselective intramolecular oxidative coupling of a dibrominated dihydrostilbene. T

Bromophenols as Candida albicans isocitrate lyase inhibitors

A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against Gram-positive and, Gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl) methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5- dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans.

COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE

Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinophathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.