38422-62-7

Usage

Uses

Used in Pharmaceutical Industry:
5-TERT-BUTYL-2-METHYLFURAN-3-CARBOXYLIC ACID is used as a pharmaceutical candidate for its anti-inflammatory and neuroprotective properties, which can be leveraged for the development of drugs targeting inflammation-related conditions and neurodegenerative diseases.
Used in Materials Science:
5-TERT-BUTYL-2-METHYLFURAN-3-CARBOXYLIC ACID is used as a building block in the synthesis of novel materials with tailored properties, suitable for various industrial applications, thanks to its unique structural features.
Further studies are needed to fully understand the potential uses and benefits of this chemical compound in different industries and applications.

InChI:InChI=1/C10H14O3/c1-6-7(9(11)12)5-8(13-6)10(2,3)4/h5H,1-4H3,(H,11,12)/p-1

Upstream product

• 38453-94-0 2-methyl-5-(tert-butyl)furan-3-carboxylic acid ethyl ester 
• 28921-35-9 2-methyl-3-ethoxycarbonyl-furan 
• 38453-93-9 ethyl 2-acetyl-5,5-dimethyl-4-oxopentanoate 
• 13547-70-1 1-chloro-3,3-dimethyl-butan-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1)

All-trans-retinoic acid (ATRA), the biologically active metabolite of vitamin A, is used medicinally for the treatment of hyperproliferative diseases and cancers. However, it is easily metabolized. In this study, the leading compound S8 was found based on virtual screening. To improve the activity of the leading compound S8, a series of novel S8 derivatives were designed, synthesized and evaluated for their in vitro biological activities. All of the prepared compounds showed that substituting the 5-chloro-3-methyl-1-phenyl-1H-pyrazole group for the 2-tertbutyl-5-methylfuran scaffold led to a clear increase in the biological activity. The most promising compound 32, with a CYP26A1 IC50 value of 1.36 μM (compared to liarozole (IC50 = 2.45 μM) and S8 (IC50 = 3.21 μM)) displayed strong inhibitory and differentiation activity against HL60 cells. In addition, the study focused on the effect of β-phenylalanine, which forms the coordination bond with the heme of CYP26A1. These studies suggest that the compound 32 can be used as an appropriate candidate for future development.