384331-58-2

Basic information

• Product Name: (3aR,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-thione
• Synonyms: (3aR,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-thione
• CAS NO: 384331-58-2
• Molecular Weight: 328.23
• Mol File: 384331-58-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3aR,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-thione(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-thione(384331-58-2)
• EPA Substance Registry System: (3aR,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-thione(384331-58-2)

Safety Data

• Hazardous Substances Data: 384331-58-2(Hazardous Substances Data)

Upstream product

• 384331-56-0 (4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (2-bromo-phenyl)-amide 
• 615-36-1 2-bromoaniline 
• 25581-41-3 D-erythronolactone acetonide 
• 384331-57-1 (3aR,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-one 

Downstream Products

• 384331-59-3 [(3aS,6aR)-5-(2-Bromo-phenyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-(4E)-ylidene]-acetic acid ethyl ester 

Relevant articles and documents

Asymmetric synthesis of a tetracyclic model for the aziridinomitosenes

The conversion of (-)-2,3-O-isopropylidene-D-erythronolactone (9) into the N-phosphorylated aziridine 20, a model for the fundamental structure of aziridinomitosenes, has been accomplished in 11 steps by way of the vinylogous urethane 13. Key steps include the preparation of 13 by a Reformatsky reaction on a thiolactam precursor, Heck cyclisation of 13 to form the indole ring, and aziridine synthesis via a cyclic sulfite.