3845-11-2

Upstream product

• 1373401-81-0 N-cyclohexyl-3,4-dihydro-4-oxo-2H-chromene-2-carboxamide 
• 39079-62-4 chromone-3-carboxylic acid 
• 931-53-3 Cyclohexyl isocyanide 
• 4940-39-0 acide chromone carboxylique-2 
• 108-91-8 cyclohexylamine 

Relevant academic research and scientific papers

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

Conjugate addition of isocyanides to chromone 3-carboxylic acid: An efficient one-pot synthesis of chroman-4-one 2-carboxamides

We report a novel Lewis acid catalysed tandem reaction of isocyanides, chromone 3-carboxylic acid and nucleophiles. An experimentally very simple procedure, involving the use of microwave irradiation in the presence of a Lewis acid catalyst, affords a representative collection of chromone-2-carboxamides and chromone-2-carboxamido-3-esters in high yields, in just a few minutes. Such an unprecedented strategy is formally equivalent to a conjugate addition of isocyanides to Michael acceptors.

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

A project focused on the discovery of new chemical entities (NCEs) as AR ligands that incorporate a benzo-γ-pyrone [(4H)-1-benzopyran-4-one] substructure has been developed. Accordingly, two series of novel chromone carboxamides placed at positions C2 (co

Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors

Two series of novel chromone derivatives were synthesized and investigated for their ability to inhibit the activity of monoamine oxidase. The SAR data indicate that chromone derivatives with substituents in position 3 of γ-pyrone nucleus act preferably a