38463-33-1

Basic information

• Product Name: Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)
• Synonyms: Thiazolo[4,5-f]quinoline, 2-methyl- (9CI);2-Methylthiazolo[4,5-f]quinoline
• CAS NO: 38463-33-1
• Molecular Formula: C11H8N2S
• Molecular Weight: 200.25962
• Product Categories: BENZOTHIAZOLE
• Mol File: 38463-33-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)(38463-33-1)
• EPA Substance Registry System: Thiazolo[4,5-f]quinoline, 2-methyl- (9CI)(38463-33-1)

Safety Data

• Hazardous Substances Data: 38463-33-1(Hazardous Substances Data)

Upstream product

• 404850-19-7 5-thioacetamidoquinoline 
• 90221-50-4 N-(2-bromo-5-nitrophenyl)acetamide 
• 2941-66-4 2-methyl-5-nitrobenzothiazole 
• 13382-43-9 2-methyl-5-aminobenzothiazole 
• 7664-93-9 sulfuric acid 
• 56-81-5 glycerol 

Relevant articles and documents

An expedient synthesis of novel 2-substituted thiazolo[4,5-f]isoquinolines/ quinolines and benzo[1,2-d:4,3-d']bisthiazoles and their potential as inhibitors of COX-1 and COX-2

An efficient, general synthesis of 2-substituted thiazolo[4,5-f] isoquinolines, thiazolo[4,5-f]-quinolines and benzo[1,2-d:4,3-d']bisthiazoles has been accomplished from 5-nitroisoquinoline/quinoline and 6-nitrobenzothiazole, respectively, and all the products have been thoroughly identified spectroscopically (IR, 1H and 13C NMR, LR/HR EI/FAB/ESI-MS). The synthesis of thiazolo[4,5-f]isoquinolines constitutes the first synthesis of this class of heteroarenes. Eighteen compounds, covering all three types, were screened for inhibition of COX-1 and COX-2, and some of them showed moderate activities. ARKAT-USA, Inc.