38468-93-8Relevant academic research and scientific papers
A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions
Dave, Chaitanya G.,Shah, Dhaval A.,Agrawal, Yadvendra K.
, p. 885 - 887 (2007/10/03)
A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.
