3847-29-8 Usage
Uses
Used in Pharmaceutical Industry:
ERYTHROMYCIN LACTOBIONATE (200 MG) is used as an antibiotic for the treatment of serious infections. It helps reduce the prevalence of drug-resistant bacteria and maintains the efficacy of other antibacterial drugs. The antibiotic is administered intravenously to achieve high plasma levels, making it effective against a wide range of bacterial infections.
Used in Medical Treatments:
ERYTHROMYCIN LACTOBIONATE (200 MG) is used as a macrolide antibacterial agent to inhibit bacterial protein synthesis by targeting the 50S ribosomal subunit. This action blocks the progression of nascent polypeptide chains, effectively treating various bacterial infections. It is particularly useful in cases where other antibiotics may not be as effective or when there is a need to target specific bacterial genera.
Originator
Erythrocin,Abbott,US,1954
Manufacturing Process
A solution of erythromycin free base is prepared by dissolving 8.0 grams of
erythromycin in 25 cc of acetone. 4.0 grams of lactobiono-delta-lactone is
dissolved in 25 cc of water. The free lactobionic acid is formed in this solution
and it has the molecular formula C12H22O12. The two solutions are mixed and
evaporated to a gummy residue. This residue is dissolved in 60 cc of water
and the solution is frozen and dried in vacuum by lyophilization. The dried
residue of erythromycin lactobionate is a white amorphous powder and weighs
11.7 grams. The reaction product has an activity against B. subtilis of 420units per milligram. Its solubility in water is about 200 mg/cc and the melting
point of the white powdery reaction product is 145° to 150°C.
Therapeutic Function
Antibacterial
Check Digit Verification of cas no
The CAS Registry Mumber 3847-29-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,4 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3847-29:
(6*3)+(5*8)+(4*4)+(3*7)+(2*2)+(1*9)=108
108 % 10 = 8
So 3847-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C37H67NO13.C12H22O12/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;13-1-3(15)10(7(18)8(19)11(21)22)24-12-9(20)6(17)5(16)4(2-14)23-12/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;3-10,12-20H,1-2H2,(H,21,22)/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-;3-,4-,5+,6+,7-,8-,9-,10-,12+/m11/s1
3847-29-8Relevant academic research and scientific papers
HYDRATES OF ERYTHROMYCIN SALTS, THE PREPARATION AND THE USE THEREOF
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Page/Page column 9-10, (2011/04/24)
The present invention relates to a macrolide derivative as well as preparation and use thereof. The macrolide derivative of the present invention, i.e., a hydrate of erythromycin salts, has a molecular formula of C37H67NO13·A·nH2O, n=1.0-11.0, in which A is an organic acid or an organic acids, selected from lactobionic acid, thiocyanic acid, maleic acid, fumaric acid, thiocyanic acid, acetic acid, methanesulfonic acid, benzenesulfonic acid, nicotinic acid, lactic acid, citric acid, tartaric acid, aspartic acid, glutamic acid and phosphoric acid, the hydrate has good water solubility and better storage stability, which is suitable for the manufacture of a medicament for the treatment and prophylaxis of infectious diseases in human or animal caused by Gram-positive or negative bacteria.
