38470-28-9

Usage

Uses

Used in Pharmaceutical Industry:
8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with improved therapeutic properties.
Used in Medicinal Chemistry Research:
As a heterocyclic compound, 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE is employed in medicinal chemistry research to explore its pharmacological properties and biological activities, which may lead to the discovery of novel therapeutic agents.
Used in Drug Discovery:
8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE is utilized in drug discovery processes due to its unique structure and properties, which may offer new avenues for the treatment of various diseases and conditions.
Used in Organic Chemistry:
8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE serves as a valuable building block in organic chemistry, facilitating the synthesis of complex organic molecules and contributing to the advancement of chemical knowledge and applications.

InChI:InChI=1/C9H8FNO/c10-7-3-1-2-6-8(12)4-5-11-9(6)7/h1-3,11H,4-5H2

Upstream product

• 348-54-9 2-Fluoroaniline 
• 38470-19-8 3-(o-fluorophenylamino)propionic acid 

Downstream Products

• 825-22-9 3-fluoroanthranilic acid 
• 75414-02-7 8-fluoro-1,2,3,4-tetrahydroquinoline 

Relevant academic research and scientific papers

2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as preparation method and application thereof

The invention discloses 2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as a preparation method and application thereof. The structural formula of the derivatives is as shown in a formula (I): (the formula is as shown in the description), wherein R1 is halogen, alkyl or alkoxy; R2 is hydrogen, halogen or alkoxy; R3 is hydrogen or halogen; R4 is hydrogen or halogen; X is hydrogen, acetyl or nitryl; and Y is hydrogen or phenyl. The derivatives can obviously inhibit proliferation of tumor cells, and has significant inhibition effect on multiple cancer cell strains such asbreast cancer cells, melanoma cells and prostatic cancer cells; and the anti-tumor activity is obviously better than that of a broad-spectrum anti-cancer medicine cis-platinum. In addition, the preparation process of the derivatives is simple, the conditions are mild, the sources of the raw materials are rich, the production cost is low, and potential medicinal value and good application prospectin the aspect of preparing a novel anti-tumor medicine are achieved.

COMPOUND HAVING 11 ?-HSD1 INHIBITORY ACTIVITY

The present invention provides compounds having excellent 11β-HSD1 inhibitory activity. A compound represented by the following formula (I): [wherein X1 represents an oxygen atom, or the formula -(CR11R12)p-, etc., Y1 represents a hydrogen atom, a hydroxyl group, etc., Z1 represents an oxygen atom or the formula -(NR14)-, R1 represents a hydrogen atom, a halogen atom, a cyano group, a C1-4 alkyl group, a C1-4 alkyl group substituted with 1 to 3 halogen atoms, a C1-4 alkoxy group, a C1-4 alkoxycarbonyl group, a carboxyl group, a carbamoyl group, or an amino group, and m represents an integer of 1 or 2, and R2 represents a hydrogen atom or a C1-4 alkyl group, and n represents an integer of 1 or 2].

Process for the preparation of 3- and/or 5-substituted anthranilic acids

Anthranilic acids substituted in the 3- and/or 5-position are valuable intermediates for the production of agricultural chemicals. These substituted anthranilic acids can be obtained in good yield without undesirable isomeric byproducts by the oxidative r