38470-73-4Relevant academic research and scientific papers
Identification of Indole-Based Chalcones: Discovery of a Potent, Selective, and Reversible Class of MAO-B Inhibitors
Sasidharan, Rani,Manju, Sreedharannair Leelabaiamma,U?ar, Gülberk,Baysal, Ipek,Mathew, Bijo
, p. 627 - 637 (2016)
A series of 11 indole-based chalcones (IC1–11) with various electron donating and withdrawing groups at the para position of the phenyl ring B were synthesized. All the compounds were tested for their human monoamine oxidase (hMAO)-A and hMAO-B inhibitory
Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors
Shu, Bing,Yu, Qian,Hu, De-xuan,Che, Tong,Zhang, Shang-shi,Li, Ding
supporting information, (2020/01/08)
A series of novel indole-pyrazoline hybrid derivatives were designed, synthesized, and evaluated for topoisomerase 1 (Top1) inhibitory activity. Top1-mediated relaxation assays showed that our synthesized compounds had variable Top1 inhibitory activity. A
Design, docking, and synthesis of some new pyrazoline and pyranopyrazole derivatives as anti-inflammatory agents
Ismail, Magda M. F.,Khalifa, Nagy M.,Fahmy, Hoda H.,Nossier, Eman S.,Abdulla, Mohamed M.
, p. 450 - 458 (2014/04/17)
Design and synthesis of some novel pyrazoline and pyranopyrazole derivatives as potential anti-inflammatory agents are described. Most of the compounds were tested for their anti-inflammatory (in vitro and in vivo) and ulcerogenic activities. In all teste
